Reactome | IFN alpha/beta binds to IFNAR2

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IFN alpha/beta binds to IFNAR2 Show undefined attributes

authored	[InstanceEdit:909728] Garapati, P V, 2010-07-07
category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:909728] Garapati, P V, 2010-07-07
dbId	909720
displayName	IFN alpha/beta binds to IFNAR2
edited	[InstanceEdit:909728] Garapati, P V, 2010-07-07
eventOf	[Pathway:R-HSA-909733] Interferon alpha/beta signaling - Homo sapiens
followingEvent	[Reaction:R-HSA-909724] Recruitment of IFNAR1 - Homo sapiens
input	[DefinedSet:R-HSA-909690] IFN alpha/beta (IFNA/B) [extracellular region] [Complex:R-HSA-918193] IFNAR2:JAK1:STAT2 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:909627] The human type I interferon receptor: NMR structure reveals the molecular basis of ligand binding [LiteratureReference:909613] Determination of residues involved in ligand binding and signal transmission in the human IFN-alpha receptor 2 [LiteratureReference:909628] Ligand-induced assembling of the type I interferon receptor on supported lipid bilayers [LiteratureReference:909617] Lateral ligand-receptor interactions on membranes probed by simultaneous fluorescence-interference detection [LiteratureReference:909639] A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state [LiteratureReference:909583] The receptor of the type I interferon family [LiteratureReference:904798] Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IFN alpha/beta binds to IFNAR2
orthologousEvent	[Reaction:R-GGA-909720] IFN alpha/beta binds to IFNAR2 - Gallus gallus [Reaction:R-SSC-909720] IFN alpha/beta binds to IFNAR2 - Sus scrofa [Reaction:R-BTA-909720] IFN alpha/beta binds to IFNAR2 - Bos taurus [Reaction:R-CFA-909720] IFN alpha/beta binds to IFNAR2 - Canis familiaris [Reaction:R-RNO-909720] IFN alpha/beta binds to IFNAR2 - Rattus norvegicus [Reaction:R-MMU-909720] IFN alpha/beta binds to IFNAR2 - Mus musculus
output	[Complex:R-HSA-918195] IFNA/B:IFNAR2:JAK1:STAT2 [plasma membrane]
regulatedBy	[NegativeRegulation:9691242] Negative regulation by 'IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]' [PositiveRegulation:9696169] Positive regulation by 'IFNAR2:JAK1:STAT2:recombinant IFNB1 [plasma membrane]'
regulationReference	[RegulationReference:9691240] Negative regulation by 'IFNAR2:JAK1:STAT2:JAK1,2 inhibitors [plasma membrane]' Selective inhibition of JAK1 and JAK2 is efficacious in rodent models of arthritis: preclinical characterization of INCB028050
releaseDate	2010-12-14
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:933762] Abdul-Sater, AA, Schindler, C, 2010-08-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-909720
summation	[Summation:909665] The ligand IFNalpha/beta (IFNA/B), interacts independently w...
updateTrackers	[UpdateTracker:9776693] Update Tracker - [Reaction:909720] IFN alpha/beta binds to IFNAR2 - v74:[addRegulator]

Referrals

(updatedInstance)	[UpdateTracker:9776693] Update Tracker - [Reaction:909720] IFN alpha/beta binds to IFNAR2 - v74:[addRegulator]
(hasEvent)	[Pathway:R-HSA-909733] Interferon alpha/beta signaling
(precedingEvent)	[Reaction:R-HSA-909724] Recruitment of IFNAR1

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