Reactome | Phosphorylation of STAT1 at Ser727

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Phosphorylation of STAT1 at Ser727 Show undefined attributes

catalystActivity	[CatalystActivity:10483216] diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of CaMKII and PKC-delta [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10483218
displayName	Phosphorylation of STAT1 at Ser727
eventOf	[Pathway:R-SSC-877300] Interferon gamma signaling - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-873927] Release of STAT1 dimer from active receptor unit - Sus scrofa
inferredFrom	[Reaction:R-HSA-909552] Phosphorylation of STAT1 at Ser727 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-SSC-873817] p-STAT1(Y701) bound to p-IFNGR1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Phosphorylation of STAT1 at Ser727
output	2 × [SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-SSC-909556] p-STAT1 dimer bound to p-IFNGR1 [plasma membrane]
precedingEvent	[Reaction:R-SSC-873922] Phosphorylation of STAT1 by JAK kinases - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-909552
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-877300] Interferon gamma signaling
(precedingEvent)	[Reaction:R-SSC-873927] Release of STAT1 dimer from active receptor unit
(inferredTo)	[Reaction:R-HSA-909552] Phosphorylation of STAT1 at Ser727

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