Reactome | Phosphorylation of STAT1 at Ser727

Phosphorylation of STAT1 at Ser727

Stable Identifier

R-HSA-909552

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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Kinases like Protein kinase C delta (PKC-delta) and Calcium/calmodulin-dependent protein kinase II (CaMK II ) can phosphorylate STAT1 at serine 727 (S727). This phosphorylation is not required for STAT1 homodimer formation, nuclear translocation and DNA binding. However, it is essential for the full transcriptional activation of STAT1.

Literature References

PubMed ID	Title	Journal	Year
11972023	Requirement of Ca2+ and CaMKII for Stat1 Ser-727 phosphorylation in response to IFN-gamma Nair, JS, Sun, W, Darnell JE, Jr, Zhang, JJ, DaFonseca, CJ, Tjernberg, A, Chait, BT	Proc Natl Acad Sci U S A	2002
15322115	Protein kinase Cdelta regulates apoptosis via activation of STAT1 Kalkofen, RL, DeVries, TA, Matassa, AA, Reyland, ME	J Biol Chem	2004