Reactome | NTRK3 binds GRB2:SOS1 through SHC1

NTRK3 binds GRB2:SOS1 through SHC1

Stable Identifier

R-HSA-9036949

Type

Reaction [uncertain]

Species

Homo sapiens

Compartment

plasma membrane, cytosol

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SHC1, phosphorylated by NTRK3 (TRKC), binds GRB2. Based on studies of NTRK1 (TRKA) and NTRK2 (TRKB2) and evidence that RAS signaling is activated downstream of NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999), GRB2 is shown in complex with RAS guanine nucleotide exchange factor SOS1.

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