NTRK3 binds GRB2:SOS1 through SHC1

Stable Identifier
R-HSA-9036949
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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NTRK3 binds GRB2:SOS1 through SHC1
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SHC1, phosphorylated by NTRK3 (TRKC), binds GRB2. Based on studies of NTRK1 (TRKA) and NTRK2 (TRKB2) and evidence that RAS signaling is activated downstream of NTRK3 (Gunn-Moore et al. 1997, Yuen and Mobley 1999), GRB2 is shown in complex with RAS guanine nucleotide exchange factor SOS1.

Participants
Input
Output
Participant Of
hasEvent
Inferred From
Ntrk3 binds Grb2 through Shc1 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-02)
Reviewed
Tsoulfas, P  (2018-05-09)
Created
Orlic-Milacic, M  (2018-02-14)