Reactome | NTRK3 phosphorylates SHC1

Schema > Reaction > Entries

authored	[InstanceEdit:9034018] Orlic-Milacic, Marija, 2018-01-02
catalystActivity	[CatalystActivity:9034876] protein tyrosine kinase activity of NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9034878] Orlic-Milacic, Marija, 2018-01-12
dbId	9034875
displayName	NTRK3 phosphorylates SHC1
edited	[InstanceEdit:9608101] Orlic-Milacic, Marija, 2018-05-09
eventOf	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9036949] NTRK3 binds GRB2:SOS1 through SHC1 - Homo sapiens
inferredFrom	[Reaction:R-NUL-9036937] Ntrk3 phosphorylates Shc1 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9034865] NTF3:p-5Y-NTRK3 homodimer:SHC1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK3 phosphorylates SHC1
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9034877] NTF3:p-5Y-NTRK3 homodimer:p-Y-SHC1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9034862] Activated NTRK3 binds SHC1 - Homo sapiens
releaseDate	2018-06-12
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9608098] Tsoulfas, Pantelis, 2018-05-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9034875
summation	[Summation:9034895] NTRK3 (TRKC), activated by NTF3 (NT-3), phosphorylates the a...

(precedingEvent)	[BlackBoxEvent:R-HSA-9036949] NTRK3 binds GRB2:SOS1 through SHC1
(hasEvent)	[Pathway:R-HSA-9034864] Activated NTRK3 signals through RAS
(inferredTo)	[Reaction:R-NUL-9036937] Ntrk3 phosphorylates Shc1

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