Reactome | MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST

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MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST Show undefined attributes

authored	[InstanceEdit:9035483] Jassal, Bijay, 2018-01-23
catalystActivity	[CatalystActivity:9930120] oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor of CysS248-MPST:TXN2 [mitochondrial matrix]
catalystActivityReference	[CatalystActivityReference:9930112] oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor of CysS248-MPST:TXN2 [mitochondrial matrix] Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:9035483] Jassal, Bijay, 2018-01-23
crossReference	[DatabaseIdentifier:9930108] RHEA:56301
dbId	9035484
deleted	[Deleted:9930131] Deletion of instance: 9035227
displayName	MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST
edited	[InstanceEdit:9035483] Jassal, Bijay, 2018-01-23
eventOf	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine - Homo sapiens
followingEvent	[Reaction:R-HSA-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN - Homo sapiens [Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Homo sapiens [Reaction:R-HSA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN - Homo sapiens [Reaction:R-HSA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-9034913] CysS248-MPST [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-3323048] TXN2 [mitochondrial matrix]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9034754] Polysulfides are possible H2S-derived signaling molecules in rat brain [LiteratureReference:9034766] 3-Mercaptopyruvate sulfurtransferase produces potential redox regulators cysteine- and glutathione-persulfide (Cys-SSH and GSSH) together with signaling molecules H2S2, H2S3 and H2S [LiteratureReference:9034762] Analysis of endogenous H2S and H2Sn in mouse brain by high-performance liquid chromatography with fluorescence and tandem mass spectrometric detection [LiteratureReference:3322999] Crystal structures of oxidized and reduced forms of human mitochondrial thioredoxin 2 [LiteratureReference:9012740] Structure and kinetic analysis of H2S production by human mercaptopyruvate sulfurtransferase
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST (thioredoxin)-dithiol + S-sulfanyl-L-cysteinyl-(protein) => (thioredoxin)-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-(protein)
orthologousEvent	[Reaction:R-MMU-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Mus musculus [Reaction:R-DDI-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Dictyostelium discoideum [Reaction:R-CEL-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Caenorhabditis elegans [Reaction:R-GGA-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Gallus gallus [Reaction:R-XTR-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Xenopus tropicalis [Reaction:R-DRE-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Danio rerio [Reaction:R-SSC-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Sus scrofa [Reaction:R-BTA-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Bos taurus [Reaction:R-RNO-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Rattus norvegicus
output	[EntityWithAccessionedSequence:R-HSA-3323059] 2xHC-TXN2 [mitochondrial matrix] [SimpleEntity:R-ALL-9930114] disulfanide [mitochondrial matrix] [EntityWithAccessionedSequence:R-HSA-9012720] MPST [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Homo sapiens
previousReviewStatus	[ReviewStatus:9821385] four stars
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9035947] Kimura, Hideo, 2018-01-25 [InstanceEdit:9939375] Hill, David P, 2025-02-25
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9035484
summation	[Summation:9035481] Hydrogen polysulfanides, which have diverse regulatory effec...
updateTrackers	[UpdateTracker:9775196] Update Tracker - [Reaction:9035484] CysS248-MPST:TXN2 dissociates - v80:[add_removeOutput] [UpdateTracker:9939790] Update Tracker - [Reaction:9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - v92:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText, removeCatalystActivity]

Referrals

(updatedInstance)	[UpdateTracker:9775196] Update Tracker - [Reaction:9035484] CysS248-MPST:TXN2 dissociates - v80:[add_removeOutput] [UpdateTracker:9939790] Update Tracker - [Reaction:9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - v92:[add_removeInput, add_removeLiteratureReference, add_removeOutput, modifyText, removeCatalystActivity]
(replacementInstances)	[Deleted:9930131] Deletion of instance: 9035227
(hasEvent)	[Pathway:R-HSA-1614558] Degradation of cysteine and homocysteine
(precedingEvent)	[Reaction:R-HSA-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN [Reaction:R-HSA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN [Reaction:R-HSA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR [Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST

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