Reactome | Degradation of cysteine and homocysteine

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Degradation of cysteine and homocysteine Show undefined attributes

authored	[InstanceEdit:1237120] Stephan, R, 2010-10-24
created	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
dbId	1614558
displayName	Degradation of cysteine and homocysteine
edited	[InstanceEdit:1614621] Jassal, Bijay, 2011-09-29
eventOf	[Pathway:R-HSA-1614635] Sulfur amino acid metabolism - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:10172] sulfur amino acid catabolic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-1614631] Homocysteine is degraded to oxobutanoate and H2S - Homo sapiens [Reaction:R-HSA-1614614] Cysteine is degraded to serine and H2S - Homo sapiens [Reaction:R-HSA-1614645] CDO1:Fe2+ oxidises L-Cys to 3-Sulfinoalanine - Homo sapiens [Reaction:R-HSA-1655443] PXKLP-K305-CSAD decarboxylates 3-sulfinoalanine to hypotaurine - Homo sapiens [Reaction:R-HSA-6814153] ADO oxidises 2AET to HTAU - Homo sapiens [Reaction:R-HSA-6814165] PXLP-K333-GADL1 decarboxylates CSA to HTAU - Homo sapiens [Reaction:R-HSA-1655453] FMO1:FAD oxidizes HTAU to TAU - Homo sapiens [Reaction:R-HSA-1614567] Excess homocysteine yields homolanthionine and H2S - Homo sapiens [Reaction:R-HSA-1614591] Excess cysteine yields lanthionine and H2S - Homo sapiens [Reaction:R-HSA-9012597] GOT2 dimer transfers amino group from L-Cys to 2OG to form 3MPYR and Glu - Homo sapiens [Reaction:R-HSA-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Homo sapiens [Reaction:R-HSA-9035227] TXN2 binds CysS248-MPST - Homo sapiens [Reaction:R-HSA-9035484] CysS248-MPST:TXN2 dissociates - Homo sapiens [Reaction:R-HSA-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR - Homo sapiens [Reaction:R-HSA-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN - Homo sapiens [Reaction:R-HSA-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN - Homo sapiens [Reaction:R-HSA-9013198] TST transfers sulfur from S2O3(2-) to HCN to form HSCN - Homo sapiens [Pathway:R-HSA-1614517] Sulfide oxidation to sulfate - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:1614574] Dealing with methionine/homocysteine sulfur: cysteine metabolism to taurine and inorganic sulfur
modified	[InstanceEdit:10931649] Wright, Adam, 2024-03-08
name	Degradation of cysteine and homocysteine
orthologousEvent	[Pathway:R-PFA-1614558] Degradation of cysteine and homocysteine - Plasmodium falciparum [Pathway:R-SCE-1614558] Degradation of cysteine and homocysteine - Saccharomyces cerevisiae [Pathway:R-SPO-1614558] Degradation of cysteine and homocysteine - Schizosaccharomyces pombe [Pathway:R-DDI-1614558] Degradation of cysteine and homocysteine - Dictyostelium discoideum [Pathway:R-CEL-1614558] Degradation of cysteine and homocysteine - Caenorhabditis elegans [Pathway:R-DME-1614558] Degradation of cysteine and homocysteine - Drosophila melanogaster [Pathway:R-GGA-1614558] Degradation of cysteine and homocysteine - Gallus gallus [Pathway:R-XTR-1614558] Degradation of cysteine and homocysteine - Xenopus tropicalis [Pathway:R-DRE-1614558] Degradation of cysteine and homocysteine - Danio rerio [Pathway:R-SSC-1614558] Degradation of cysteine and homocysteine - Sus scrofa [Pathway:R-BTA-1614558] Degradation of cysteine and homocysteine - Bos taurus [Pathway:R-CFA-1614558] Degradation of cysteine and homocysteine - Canis familiaris [Pathway:R-RNO-1614558] Degradation of cysteine and homocysteine - Rattus norvegicus [Pathway:R-MMU-1614558] Degradation of cysteine and homocysteine - Mus musculus
releaseDate	2011-12-06
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:1660489] D'Eustachio, P, 2011-10-13
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-1614558
summation	[Summation:1614647] While in humans excess methionine is converted to homocystei...

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[Pathway:R-HSA-1614635] Sulfur amino acid metabolism

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