Reactome | MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST

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MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST Show undefined attributes

catalystActivity	[CatalystActivity:10544862] oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor of CysS248-MPST:TXN2 [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10447035] Weiser, Joel, 2026-03-16
dbId	10544864
displayName	MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST
eventOf	[Pathway:R-SSC-1614558] Degradation of cysteine and homocysteine - Sus scrofa
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-SSC-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN - Sus scrofa [Reaction:R-SSC-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN - Sus scrofa [Reaction:R-SSC-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR - Sus scrofa [Reaction:R-SSC-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Sus scrofa
inferredFrom	[Reaction:R-HSA-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST - Homo sapiens
input	[EntityWithAccessionedSequence:R-SSC-9034913] MPST [mitochondrial matrix] [EntityWithAccessionedSequence:R-SSC-3323048] TXN2 [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST (thioredoxin)-dithiol + S-sulfanyl-L-cysteinyl-(protein) => (thioredoxin)-disulfide + H(+) + hydrogen sulfide + L-cysteinyl-(protein)
output	[SimpleEntity:R-ALL-9930114] disulfanide [mitochondrial matrix] [EntityWithAccessionedSequence:R-SSC-9012720] MPST [mitochondrial matrix] [EntityWithAccessionedSequence:R-SSC-3323059] TXN2 [mitochondrial matrix]
precedingEvent	[Reaction:R-SSC-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST - Sus scrofa
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49633] Sus scrofa
stId	R-SSC-9035484
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-SSC-1614558] Degradation of cysteine and homocysteine
(precedingEvent)	[Reaction:R-SSC-9013533] MPST transfers sulfur from sulfanegen to HCN to form HSCN [Reaction:R-SSC-9013471] MPST transfers sulfur from 3MPYR to HCN to form HSCN [Reaction:R-SSC-9012721] MPST transfers sulfur atom from 3MPYR to HSO3- to form S2O3(2-) and PYR [Reaction:R-SSC-9034756] MPST transfers sulfur atom from 3MPYR to form CysS248-MPST
(inferredTo)	[Reaction:R-HSA-9035484] MPST and TXN2 enable the synthesis of disulfanide from CysS248-MPST

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