Reactome | ABO blood group biosynthesis

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ABO blood group biosynthesis Show undefined attributes

authored	[InstanceEdit:9033806] Jassal, Bijay, 2017-12-28
created	[InstanceEdit:9033806] Jassal, Bijay, 2017-12-28
dbId	9033807
displayName	ABO blood group biosynthesis
edited	[InstanceEdit:9033806] Jassal, Bijay, 2017-12-28
eventOf	[Pathway:R-HSA-9033658] Blood group systems biosynthesis - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:25293] oligosaccharide biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Homo sapiens [Reaction:R-HSA-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Homo sapiens [Reaction:R-HSA-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Homo sapiens [Reaction:R-HSA-9033961] ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC - Homo sapiens [BlackBoxEvent:R-HSA-9037612] H antigen-sec translocates from Golgi lumen to extracellular region - Homo sapiens [Reaction:R-HSA-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Homo sapiens [Reaction:R-HSA-9034053] sABO-B:Mn2+ transfers Gal to H antigen-sec to form B antigen - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033670] Blood type biochemistry and human disease [LiteratureReference:9034037] Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme [LiteratureReference:9034075] Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system [LiteratureReference:9038583] The H blood group system
maxDepth	2
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	ABO blood group biosynthesis
orthologousEvent	[Pathway:R-BTA-9033807] ABO blood group biosynthesis - Bos taurus [Pathway:R-CEL-9033807] ABO blood group biosynthesis - Caenorhabditis elegans [Pathway:R-XTR-9033807] ABO blood group biosynthesis - Xenopus tropicalis [Pathway:R-DRE-9033807] ABO blood group biosynthesis - Danio rerio [Pathway:R-SSC-9033807] ABO blood group biosynthesis - Sus scrofa [Pathway:R-CFA-9033807] ABO blood group biosynthesis - Canis familiaris [Pathway:R-RNO-9033807] ABO blood group biosynthesis - Rattus norvegicus [Pathway:R-MMU-9033807] ABO blood group biosynthesis - Mus musculus
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9033807
summation	[Summation:9036957] Perhaps the most important and widely studied blood group is...

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[Pathway:R-HSA-9033658] Blood group systems biosynthesis

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