Reactome | FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC

Schema > Reaction > Entries

FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC Show undefined attributes

authored	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
catalystActivity	[CatalystActivity:9034052] fucosyltransferase activity of FUT1 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
dbId	9033949
displayName	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC
edited	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
eventOf	[Pathway:R-HSA-9033807] ABO blood group biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9603983] FUT2 transfers Fuc to LeX to form LeY - Homo sapiens [Reaction:R-HSA-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Homo sapiens [Reaction:R-HSA-9033961] ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC - Homo sapiens
input	[SimpleEntity:R-ALL-205683] GDP-Fuc [Golgi lumen] [SimpleEntity:R-ALL-9033790] Type 2 chain [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9034049] Molecular cloning, sequence, and expression of a human GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase cDNA that can form the H blood group antigen [LiteratureReference:9034037] Wide variety of point mutations in the H gene of Bombay and para-Bombay individuals that inactivate H enzyme [LiteratureReference:9034075] Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC
orthologousEvent	[Reaction:R-BTA-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Bos taurus [Reaction:R-CEL-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Caenorhabditis elegans [Reaction:R-XTR-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Xenopus tropicalis [Reaction:R-SSC-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Sus scrofa [Reaction:R-RNO-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Rattus norvegicus [Reaction:R-MMU-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Mus musculus
output	[SimpleEntity:R-ALL-205689] GDP [Golgi lumen] [SimpleEntity:R-ALL-9033793] H antigen-RBC [Golgi lumen]
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033949
summation	[Summation:9037569] The H antigen is formed with the addition of a fucose (Fuc) ...

Referrals

(precedingEvent)	[Reaction:R-HSA-9603983] FUT2 transfers Fuc to LeX to form LeY [Reaction:R-HSA-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC [Reaction:R-HSA-9033961] ABO-B:Mn2+ transfers Gal to H antigen-RBC to form B antigen-RBC
(hasEvent)	[Pathway:R-HSA-9033807] ABO blood group biosynthesis