Reactome | sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec

Schema > Reaction > Entries

sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec Show undefined attributes

authored	[InstanceEdit:9034056] Jassal, Bijay, 2018-01-02
catalystActivity	[CatalystActivity:9034044] glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity of sABO-A:Mn2+ [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:9034056] Jassal, Bijay, 2018-01-02
dbId	9034042
displayName	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec
edited	[InstanceEdit:9034056] Jassal, Bijay, 2018-01-02
eventOf	[Pathway:R-HSA-9033807] ABO blood group biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-9034101] H antigen-sec [extracellular region] [SimpleEntity:R-ALL-9034046] UDP-GalNAc [extracellular region]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033947] Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif [LiteratureReference:9033952] The structural basis for specificity in human ABO(H) blood group biosynthesis [LiteratureReference:9033943] Molecular genetic basis of the histo-blood group ABO system [LiteratureReference:9033935] Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli [LiteratureReference:9033936] Amino acid residue at codon 268 determines both activity and nucleotide-sugar donor substrate specificity of human histo-blood group A and B transferases. In vitro mutagenesis study [LiteratureReference:9034036] ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec
orthologousEvent	[Reaction:R-XTR-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Xenopus tropicalis [Reaction:R-DRE-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Danio rerio [Reaction:R-CFA-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Canis familiaris [Reaction:R-RNO-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Rattus norvegicus [Reaction:R-MMU-9034042] sABO-A:Mn2+ transfers GalNAc to H antigen-sec to form A antigen-sec - Mus musculus
output	[SimpleEntity:R-ALL-9037066] A antigen-sec [extracellular region] [SimpleEntity:R-ALL-417888] UDP [extracellular region]
precedingEvent	[BlackBoxEvent:R-HSA-9037612] H antigen-sec translocates from Golgi lumen to extracellular region - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9034042
summation	[Summation:9037616] As well as being a Golgi membrane resident, the histo-blood ...

Referrals

(hasEvent)

[Pathway:R-HSA-9033807] ABO blood group biosynthesis