Reactome | FUT2 transfers Fuc to Type 1 chains to form H antigen-sec

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FUT2 transfers Fuc to Type 1 chains to form H antigen-sec Show undefined attributes

authored	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
catalystActivity	[CatalystActivity:9036986] galactoside 2-alpha-L-fucosyltransferase activity of FUT2 [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:9036983] Jassal, Bijay, 2018-02-15
dbId	9036987
displayName	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec
edited	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
eventOf	[Pathway:R-HSA-9033807] ABO blood group biosynthesis - Homo sapiens
followingEvent	[Reaction:R-HSA-9603982] FUT2 transfers Fuc to LeA to form LeB - Homo sapiens [BlackBoxEvent:R-HSA-9037612] H antigen-sec translocates from Golgi lumen to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-205683] GDP-Fuc [Golgi lumen] [SimpleEntity:R-ALL-9036984] Type 1 chain [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9034035] Sequence and expression of a candidate for the human Secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype [LiteratureReference:9034048] Structure and expression of the gene encoding secretor-type galactoside 2-alpha-L-fucosyltransferase (FUT2) [LiteratureReference:9034041] Molecular basis for H blood group deficiency in Bombay (Oh) and para-Bombay individuals [LiteratureReference:9034075] Missense mutation of FUT1 and deletion of FUT2 are responsible for Indian Bombay phenotype of ABO blood group system
maxDepth	1
modified	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name	FUT2 transfers Fuc to Type 1 chains to form H antigen-sec
orthologousEvent	[Reaction:R-BTA-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Bos taurus [Reaction:R-CEL-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Caenorhabditis elegans [Reaction:R-XTR-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Xenopus tropicalis [Reaction:R-SSC-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Sus scrofa [Reaction:R-CFA-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Canis familiaris [Reaction:R-RNO-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Rattus norvegicus [Reaction:R-MMU-9036987] FUT2 transfers Fuc to Type 1 chains to form H antigen-sec - Mus musculus
output	[SimpleEntity:R-ALL-205689] GDP [Golgi lumen] [SimpleEntity:R-ALL-9037036] H antigen-sec [Golgi lumen]
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9036987
summation	[Summation:9037570] The H antigen is formed by the addition of a fucose (Fuc) su...

Referrals

(precedingEvent)	[Reaction:R-HSA-9603982] FUT2 transfers Fuc to LeA to form LeB [BlackBoxEvent:R-HSA-9037612] H antigen-sec translocates from Golgi lumen to extracellular region
(hasEvent)	[Pathway:R-HSA-9033807] ABO blood group biosynthesis