Reactome | ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC

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ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC Show undefined attributes

authored	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
catalystActivity	[CatalystActivity:9034055] glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity of ABO-A:Mn2+ [Golgi membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:20699] Golgi membrane
created	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
dbId	9033959
displayName	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC
edited	[InstanceEdit:9033946] Jassal, Bijay, 2017-12-29
eventOf	[Pathway:R-HSA-9033807] ABO blood group biosynthesis - Homo sapiens
input	[SimpleEntity:R-ALL-9033793] H antigen-RBC [Golgi lumen] [SimpleEntity:R-ALL-735700] UDP-GalNAc [Golgi lumen]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9033947] Structural effects of naturally occurring human blood group B galactosyltransferase mutations adjacent to the DXD motif [LiteratureReference:9033952] The structural basis for specificity in human ABO(H) blood group biosynthesis [LiteratureReference:9033943] Molecular genetic basis of the histo-blood group ABO system [LiteratureReference:9033935] Donor substrate specificity of recombinant human blood group A, B and hybrid A/B glycosyltransferases expressed in Escherichia coli [LiteratureReference:9033936] Amino acid residue at codon 268 determines both activity and nucleotide-sugar donor substrate specificity of human histo-blood group A and B transferases. In vitro mutagenesis study [LiteratureReference:9034036] ABO(H) blood group A and B glycosyltransferases recognize substrate via specific conformational changes
maxDepth	1
modified	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
name	ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC
orthologousEvent	[Reaction:R-XTR-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Xenopus tropicalis [Reaction:R-DRE-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Danio rerio [Reaction:R-CFA-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Canis familiaris [Reaction:R-RNO-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Rattus norvegicus [Reaction:R-MMU-9033959] ABO-A:Mn2+ transfers GalNAc to H antigen-RBC to form A antigen-RBC - Mus musculus
output	[SimpleEntity:R-ALL-9033802] A antigen-RBC [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-HSA-9033949] FUT1 transfers Fuc to Type 2 chains to form H antigen-RBC - Homo sapiens
releaseDate	2019-03-20
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9632249] Matsui, Taei, 2018-12-17
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033959
summation	[Summation:9037575] The histo-blood group ABO system transferase (ABO) is the ba...

Referrals

(hasEvent)

[Pathway:R-HSA-9033807] ABO blood group biosynthesis