Reactome | NTRK2 promotes TIAM1 phosphorylation

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NTRK2 promotes TIAM1 phosphorylation Show undefined attributes

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
catalystActivity	[CatalystActivity:9033287] protein tyrosine kinase activity of BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]
category	uncertain
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9033286] Orlic-Milacic, Marija, 2017-12-20
dbId	9033284
displayName	NTRK2 promotes TIAM1 phosphorylation
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5 - Homo sapiens
followingEvent	[Reaction:R-HSA-9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1 - Homo sapiens
inferredFrom	[BlackBoxEvent:R-NUL-9033333] Ntrk2 promotes Tiam1 phosphorylation - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-HSA-9033279] BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK2 promotes TIAM1 phosphorylation
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-HSA-9033288] BDNF:p-5Y,S479-NTRK2:p-Y829-TIAM1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9033276] NTRK2 binds TIAM1 - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-9033284
summation	[Summation:9033285] Upon binding to NTRK2 (TRKB), TIAM1 is phosphorylated at tyr...

Referrals

(hasEvent)	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5
(precedingEvent)	[Reaction:R-HSA-9033292] NTRK2 and CDK5 promote activation of RAC1 by TIAM1
(inferredTo)	[BlackBoxEvent:R-NUL-9033333] Ntrk2 promotes Tiam1 phosphorylation

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