NTRK2 promotes TIAM1 phosphorylation

Stable Identifier
R-HSA-9033284
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
plasma membrane, cytosol
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NTRK2 promotes TIAM1 phosphorylation
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Upon binding to NTRK2 (TRKB), TIAM1 is phosphorylated at tyrosine residue Y829, presumably by NTRK2, but this has not been shown directly (Lai et al. 2012).

Participants
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Output
Participates
as an event of
Catalyst Activity

protein tyrosine kinase activity of BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]

Physical Entity
BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane] (Homo sapiens)
Activity
protein tyrosine kinase activity (GO:0004713)
Inferred From
Ntrk2 promotes Tiam1 phosphorylation (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-01-05)
Reviewed
Castrén, E  (2018-02-13)
Antila, H  (2018-02-13)
Created
Orlic-Milacic, M  (2017-12-20)
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