Upon binding to NTRK2 (TRKB), TIAM1 is phosphorylated at tyrosine residue Y829, presumably by NTRK2, but this has not been shown directly (Lai et al. 2012).
protein tyrosine kinase activity of BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]
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