Reactome | NTRK2 binds TIAM1

Schema > Reaction > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9033277] Orlic-Milacic, Marija, 2017-12-20
dbId	9033276
displayName	NTRK2 binds TIAM1
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5 - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9033284] NTRK2 promotes TIAM1 phosphorylation - Homo sapiens
inferredFrom	[Reaction:R-NUL-9033304] Ntrk2 binds Tiam1 - Mus musculus
input	[Complex:R-HSA-9032862] BDNF:p-5Y,S479-NTRK2 homodimer [plasma membrane] [EntityWithAccessionedSequence:R-HSA-195013] TIAM1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NTRK2 binds TIAM1
output	[Complex:R-HSA-9033279] BDNF:p-5Y,S479-NTRK2 homodimer:TIAM1 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9032863] CDK5 phosphorylates NTRK2 - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9033276
summation	[Summation:9033278] TIAM1, a guanine nucleotide exchange factor (GEF) for the RH...

(precedingEvent)	[BlackBoxEvent:R-HSA-9033284] NTRK2 promotes TIAM1 phosphorylation
(hasEvent)	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5
(inferredTo)	[Reaction:R-NUL-9033304] Ntrk2 binds Tiam1

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