Reactome | Activated NTRK2 binds CDK5

Schema > Reaction > Entries

authored	[InstanceEdit:9034391] Orlic-Milacic, Marija, 2018-01-05
category	binding
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:9032844] Orlic-Milacic, Marija, 2017-12-18
dbId	9032841
displayName	Activated NTRK2 binds CDK5
edited	[InstanceEdit:9037703] Orlic-Milacic, Marija, 2018-02-20
eventOf	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5 - Homo sapiens
followingEvent	[Reaction:R-HSA-9032854] NTRK2 phosphorylates CDK5 - Homo sapiens
inferredFrom	[Reaction:R-NUL-9032908] Activated Ntrk2 binds Cdk5 - Rattus norvegicus
input	[Complex:R-HSA-9026465] BDNF:p-5Y-NTRK2 homodimer [plasma membrane] [Complex:R-HSA-421107] CDK5:p35 [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	true
maxDepth	1
modified	[InstanceEdit:9865786] Orlic-Milacic, Marija, 2024-03-18
name	Activated NTRK2 binds CDK5
negativePrecedingEvent	[NegativePrecedingEvent:9865785] Futile Cycle: Activated PCLG1 dissociates from NTRK2
output	[Complex:R-HSA-9032842] BDNF:p-5Y-NTRK2 homodimer:CDK5:p35 [plasma membrane]
precedingEvent	[Reaction:R-HSA-9026464] BDNF-bound NTRK2 dimers trans-autophosphorylate - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037707] Antila, Hanna, 2018-02-13 [InstanceEdit:9037710] Castr�n, Eero, 2018-02-13
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9032841
summation	[Summation:9032843] BDNF-activated NTRK2 binds CDK5 indirectly, by interacting w...

(precedingEvent)	[Reaction:R-HSA-9032854] NTRK2 phosphorylates CDK5
(hasEvent)	[Pathway:R-HSA-9032845] Activated NTRK2 signals through CDK5
(inferredTo)	[Reaction:R-NUL-9032908] Activated Ntrk2 binds Cdk5

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