Reactome | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

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NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Show undefined attributes

authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9029533] Shamovsky, Veronica, 2017-11-20
dbId	9029569
displayName	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9024446] NR1H2 and NR1H3-mediated signaling - Homo sapiens
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-HSA-9024386] Oxysterol-induced binding of NR1H2,3:RXR to the ABCG1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9024361] Expression of ABCG1 regulated by NR1H2,3 - Homo sapiens [Reaction:R-HSA-9024326] Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex - Homo sapiens [Reaction:R-HSA-9024334] Co-repressor complex dissociates from the transcription unit of the ABCA1 gene - Homo sapiens [Reaction:R-HSA-9029551] NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex - Homo sapiens [Reaction:R-HSA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter - Homo sapiens [BlackBoxEvent:R-HSA-9605057] ABCA1 gene transcription regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9618486] miR-26 binds to the 3'UTR of the ABCA1 mRNA - Homo sapiens [Reaction:R-HSA-9624925] miR-33 binds to the 3'UTR of the ABCA1 mRNA - Homo sapiens [Reaction:R-HSA-9657791] miR-144 binds to the 3'UTR of the ABCA1 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9618479] ABCA1 mRNA is translated - Homo sapiens [Reaction:R-HSA-9619756] NR1H2 binds ABCA1 - Homo sapiens [Reaction:R-HSA-9029521] NR1H2,3 binds the ABCG5 gene - Homo sapiens [BlackBoxEvent:R-HSA-9029531] Expression of ABCG5 regulated by NR1H2,3 - Homo sapiens [Reaction:R-HSA-9029555] NR1H2,3 binds the ABCG8 gene - Homo sapiens [BlackBoxEvent:R-HSA-9029591] Expression of ABCG8 regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9035133] NR1H2,3 binds the CETP gene - Homo sapiens [BlackBoxEvent:R-HSA-9035169] Expression of CETP regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9624353] NR1H2,3 binds the PLTP gene - Homo sapiens [BlackBoxEvent:R-HSA-9624365] Expression of PLTP regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9031522] NR1H2,3 binds the APOE gene - Homo sapiens [BlackBoxEvent:R-HSA-9031512] Expression of APOE regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9031518] NR1H2,3 binds the APOC1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9031510] Expression of APOC1 regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9031521] NR1H2,3 binds the APOC2 gene - Homo sapiens [BlackBoxEvent:R-HSA-9031527] Expression of APOC2 regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9035143] NR1H2,3 binds the APOC4 gene - Homo sapiens [BlackBoxEvent:R-HSA-9035279] Expression of APOC4 regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9657786] NR1H2,3 binds the APOD gene - Homo sapiens [BlackBoxEvent:R-HSA-9657767] Expression of APOD regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9035167] NR1H2,3 binds the EEPD1 gene - Homo sapiens [BlackBoxEvent:R-HSA-9035180] Expression of EEPD1 regulated by NR1H2 or NR1H3 - Homo sapiens [Reaction:R-HSA-9035185] NR1H2,3 binds the NR1H3 gene - Homo sapiens [BlackBoxEvent:R-HSA-9035281] NR1H3 gene transcription regulated by NR1H2,3 - Homo sapiens [Reaction:R-HSA-9038545] miR-613 binds to the 3'UTR of the NR1H3 mRNA - Homo sapiens [BlackBoxEvent:R-HSA-9605052] NR1H3 mRNA is translated - Homo sapiens [Reaction:R-HSA-9618407] NR1H2,3 binds the ARL4C gene - Homo sapiens [BlackBoxEvent:R-HSA-9618394] ARL4C gene transcription regulated by NR1H2,3 - Homo sapiens [BlackBoxEvent:R-HSA-9618405] ARL4C mRNA is translated - Homo sapiens [Reaction:R-HSA-9618392] miR-26 binds to the 3'UTR of the ARL4C mRNA - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9607275] Liver X Receptors and their Agonists: Targeting for Cholesterol Homeostasis and Cardiovascular Diseases [LiteratureReference:9024375] Liver X receptor in cholesterol metabolism [LiteratureReference:9035126] Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
maxDepth	2
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux LXRs regulate gene expression linked to cholesterol transport and efflux
orthologousEvent	[Pathway:R-DME-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Drosophila melanogaster [Pathway:R-GGA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Gallus gallus [Pathway:R-DRE-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Danio rerio [Pathway:R-SSC-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Sus scrofa [Pathway:R-MMU-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Mus musculus [Pathway:R-RNO-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Rattus norvegicus [Pathway:R-CFA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Canis familiaris [Pathway:R-BTA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Bos taurus
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9029569
summation	[Summation:9607277] The liver X receptors (LXRs), LXR? (NR1H3) and LXR? (NR1H2),...

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[Pathway:R-HSA-9024446] NR1H2 and NR1H3-mediated signaling

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