Reactome | NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

Schema > Pathway > Entries

NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331709
displayName	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux
eventOf	[Pathway:R-CFA-9024446] NR1H2 and NR1H3-mediated signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-9024326] Oxysterol binds to the ABCA1 gene:NR1H2,3:RXR:NCOR:GPS2:TBL1:HDAC3 complex - Canis familiaris [Reaction:R-CFA-9024334] Co-repressor complex dissociates from the transcription unit of the ABCA1 gene - Canis familiaris [Reaction:R-CFA-9029551] NCOA1 binds the ABCA1gene:NR1H2,3:RXR:NR1H2,3 ligands complex - Canis familiaris [Reaction:R-CFA-9029561] NCOA1 recruits EP300 to the ABCA1 promoter - Canis familiaris [Reaction:R-CFA-9619756] NR1H2 binds ABCA1 - Canis familiaris
inferredFrom	[Pathway:R-HSA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux LXRs regulate gene expression linked to cholesterol transport and efflux
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9029569
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-9024446] NR1H2 and NR1H3-mediated signaling
(inferredTo)	[Pathway:R-HSA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

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