Reactome | NR1H2 and NR1H3-mediated signaling

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NR1H2 and NR1H3-mediated signaling Show undefined attributes

authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9024428] Shamovsky, Veronica, 2017-10-03
dbId	9024446
displayName	NR1H2 and NR1H3-mediated signaling
doi	10.3180/R-HSA-9024446.1
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9006931] Signaling by Nuclear Receptors - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:23772] intracellular receptor signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-HSA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Homo sapiens [Pathway:R-HSA-9031525] NR1H2 & NR1H3 regulate gene expression to limit cholesterol uptake - Homo sapiens [Pathway:R-HSA-9029558] NR1H2 & NR1H3 regulate gene expression linked to lipogenesis - Homo sapiens [Pathway:R-HSA-9031528] NR1H2 & NR1H3 regulate gene expression linked to triglyceride lipolysis in adipose - Homo sapiens [Pathway:R-HSA-9623433] NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis - Homo sapiens [Pathway:R-HSA-9632974] NR1H2 & NR1H3 regulate gene expression linked to gluconeogenesis - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9024340] Liver X receptor biology and pharmacology: new pathways, challenges and opportunities [LiteratureReference:9029532] Liver X receptors (LXRs). Part I: structure, function, regulation of activity, and role in lipid metabolism
maxDepth	3
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NR1H2 and NR1H3-mediated signaling LXR-mediated signaling
orthologousEvent	[Pathway:R-DME-9024446] NR1H2 and NR1H3-mediated signaling - Drosophila melanogaster [Pathway:R-GGA-9024446] NR1H2 and NR1H3-mediated signaling - Gallus gallus [Pathway:R-DRE-9024446] NR1H2 and NR1H3-mediated signaling - Danio rerio [Pathway:R-SSC-9024446] NR1H2 and NR1H3-mediated signaling - Sus scrofa [Pathway:R-BTA-9024446] NR1H2 and NR1H3-mediated signaling - Bos taurus [Pathway:R-CFA-9024446] NR1H2 and NR1H3-mediated signaling - Canis familiaris [Pathway:R-RNO-9024446] NR1H2 and NR1H3-mediated signaling - Rattus norvegicus [Pathway:R-MMU-9024446] NR1H2 and NR1H3-mediated signaling - Mus musculus
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-9024446
summation	[Summation:9024421] The liver X receptors LXR? (NR1H3) and LXR? (NR1H2) are memb...

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[Pathway:R-HSA-9006931] Signaling by Nuclear Receptors