Reactome | NR1H2,3 binds the APOC2 gene

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NR1H2,3 binds the APOC2 gene Show undefined attributes

authored	[InstanceEdit:9035107] Shamovsky, Veronica, 2018-01-18
category	binding
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:9031514] Shamovsky, Veronica, 2017-11-30
dbId	9031521
displayName	NR1H2,3 binds the APOC2 gene
edited	[InstanceEdit:9657765] Shamovsky, Veronica, 2019-08-09
eventOf	[Pathway:R-HSA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9031527] Expression of APOC2 regulated by NR1H2 or NR1H3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-6784670] APOC2 gene [nucleoplasm] [CandidateSet:R-HSA-9024381] NR1H2,3:RXR [nucleoplasm] [DefinedSet:R-ALL-9024383] NR1H3, NR1H2 ligands [nucleoplasm]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9035126] Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	NR1H2,3 binds the APOC2 gene LXR binds the APOC2 gene
output	[Complex:R-HSA-9031517] NR1H2,3:RXR:NR1H2,3 ligand:APOC2 gene [nucleoplasm]
releaseDate	2019-09-10
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9633727] D'Eustachio, Peter, 2018-12-29 [InstanceEdit:9657850] Cummins, Carolyn L, Repa, Joyce J, 2019-08-09
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9031521
summation	[Summation:9035124] Natural and synthetic ligands of liver X receptors (LXR?, NR...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9031527] Expression of APOC2 regulated by NR1H2 or NR1H3
(hasEvent)	[Pathway:R-HSA-9029569] NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux

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