NOTCH3 coactivator complex binds WWC1 (Kibra) gene promoter

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R-HSA-9021480
Type
Reaction [binding]
Species
Homo sapiens
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The WWC1 (Kibra) gene promoter region contains two RBPJ-binding sites, one on the sense strand and one on the antisense strand. The NOTCH3 coactivator complex binds to the RBPJ-binding site on the antisense strand (Zhang et al. 2016).

Literature References
PubMed ID Title Journal Year
27841855 Notch3 inhibits epithelial-mesenchymal transition by activating Kibra-mediated Hippo/YAP signaling in breast cancer epithelial cells

Zhang, X, Liu, X, Luo, J, Xiao, W, Ye, X, Chen, M, Li, Y, Zhang, GJ

Oncogenesis 2016
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