Reactome | ALOX15 oxidises DHA to 17(S)-Hp-DHA

Schema > Reaction > Entries

ALOX15 oxidises DHA to 17(S)-Hp-DHA Show undefined attributes

authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9022673] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
crossReference	[DatabaseIdentifier:12668425] RHEA:50841 [DatabaseIdentifier:9916403] RHEA:50841
dbId	9020275
displayName	ALOX15 oxidises DHA to 17(S)-Hp-DHA
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
eventOf	[Pathway:R-HSA-9018677] Biosynthesis of DHA-derived SPMs - Homo sapiens
followingEvent	[Reaction:R-HSA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Homo sapiens [Reaction:R-HSA-9024881] ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA - Homo sapiens [Reaction:R-HSA-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9024475] Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation [LiteratureReference:9024593] Formation of 15-lipoxygenase product from docosahexaenoic acid (22:6w3) by human platelets
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX15 oxidises DHA to 17(S)-Hp-DHA 4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
orthologousEvent	[Reaction:R-DDI-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Dictyostelium discoideum [Reaction:R-DRE-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Danio rerio [Reaction:R-SSC-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Sus scrofa [Reaction:R-BTA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Bos taurus [Reaction:R-CFA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Canis familiaris [Reaction:R-RNO-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Rattus norvegicus [Reaction:R-MMU-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Mus musculus
output	[SimpleEntity:R-ALL-9024012] 17(S)-Hp-DHA [cytosol]
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9020275
summation	[Summation:9024563] In the absence of aspirin in human whole blood, isolated leu...

Referrals

(precedingEvent)	[Reaction:R-HSA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA [Reaction:R-HSA-9024881] ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA [Reaction:R-HSA-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX
(hasEvent)	[Pathway:R-HSA-9018677] Biosynthesis of DHA-derived SPMs

Cite Us!