Reactome | ALOX15 oxidises 17(S)-Hp-DHA to PDX

Schema > Reaction > Entries

ALOX15 oxidises 17(S)-Hp-DHA to PDX Show undefined attributes

authored	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
catalystActivity	[CatalystActivity:9022673] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
dbId	9024872
displayName	ALOX15 oxidises 17(S)-Hp-DHA to PDX
edited	[InstanceEdit:9024874] Jassal, Bijay, 2017-10-10
eventOf	[Pathway:R-HSA-9018681] Biosynthesis of protectins - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-9031807] Protectins translocate from cytosol to extracellular region - Homo sapiens
input	[SimpleEntity:R-ALL-9024012] 17(S)-Hp-DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9020250] Anti-inflammatory actions of neuroprotectin D1/protectin D1 and its natural stereoisomers: assignments of dihydroxy-containing docosatrienes [LiteratureReference:9024475] Novel docosatrienes and 17S-resolvins generated from docosahexaenoic acid in murine brain, human blood, and glial cells. Autacoids in anti-inflammation [LiteratureReference:9024888] Full characterization of PDX, a neuroprotectin/protectin D1 isomer, which inhibits blood platelet aggregation
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	ALOX15 oxidises 17(S)-Hp-DHA to PDX
orthologousEvent	[Reaction:R-DDI-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Dictyostelium discoideum [Reaction:R-DRE-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Danio rerio [Reaction:R-SSC-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Sus scrofa [Reaction:R-BTA-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Bos taurus [Reaction:R-CFA-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Canis familiaris [Reaction:R-RNO-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Rattus norvegicus [Reaction:R-MMU-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Mus musculus
output	[SimpleEntity:R-ALL-9024883] PDX [cytosol]
precedingEvent	[Reaction:R-HSA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9024872
summation	[Summation:9024878] 15-lipoxygenase (ALOX15) can mediate a second lipoxygenation...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-9031807] Protectins translocate from cytosol to extracellular region
(hasEvent)	[Pathway:R-HSA-9018681] Biosynthesis of protectins