Reactome | ALOX15 oxidises DHA to 17(S)-Hp-DHA

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ALOX15 oxidises DHA to 17(S)-Hp-DHA Show undefined attributes

catalystActivity	[CatalystActivity:10209671] arachidonate 15-lipoxygenase activity of ALOX15 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10209705
displayName	ALOX15 oxidises DHA to 17(S)-Hp-DHA
eventOf	[Pathway:R-RNO-9018677] Biosynthesis of DHA-derived SPMs - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-RNO-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Rattus norvegicus [Reaction:R-RNO-9024881] ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA - Rattus norvegicus [Reaction:R-RNO-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX15 oxidises DHA to 17(S)-Hp-DHA 4Z,7Z,10Z,13Z,16Z,19Z)-docosahexaenoate + O2 => (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate
output	[SimpleEntity:R-ALL-9024012] 17(S)-Hp-DHA [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-9020275
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-9018677] Biosynthesis of DHA-derived SPMs
(precedingEvent)	[Reaction:R-RNO-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA [Reaction:R-RNO-9024881] ALOX15 dehydrogenates 17(S)-Hp-DHA to 16S,17S-epoxy-DHA [Reaction:R-RNO-9024872] ALOX15 oxidises 17(S)-Hp-DHA to PDX
(inferredTo)	[Reaction:R-HSA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA

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