Reactome | GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA

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GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA Show undefined attributes

authored	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
catalystActivity	[CatalystActivity:9020570] phospholipid-hydroperoxide glutathione peroxidase activity of GPX4-2 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
crossReference	[DatabaseIdentifier:12668430] RHEA:76716 [DatabaseIdentifier:9916420] RHEA:76716
dbId	9020273
displayName	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA
edited	[InstanceEdit:9020263] Jassal, Bijay, 2017-09-05
eventOf	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins - Homo sapiens
followingEvent	[Reaction:R-HSA-9020282] ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA - Homo sapiens [Reaction:R-HSA-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA - Homo sapiens
input	[SimpleEntity:R-ALL-9024012] 17(S)-Hp-DHA [cytosol] 2 × [SimpleEntity:R-ALL-29450] GSH [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9020573] Expression and characterization of recombinant human phospholipid hydroperoxide glutathione peroxidase [LiteratureReference:9024472] Expression of human phospholipid hydroperoxide glutathione peroxidase gene for protection of host cells from lipid hydroperoxide-mediated injury
maxDepth	1
modified	[InstanceEdit:11108703] Weiser, Joel, 2026-03-16
name	GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA (17S)-hydroperoxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + 2 glutathione => (17S)-hydroxy-(4Z,7Z,10Z,13Z,15E,19Z)-docosahexaenoate + glutathione disulfide + H2O
orthologousEvent	[Reaction:R-PFA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Plasmodium falciparum [Reaction:R-CEL-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Caenorhabditis elegans [Reaction:R-GGA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Gallus gallus [Reaction:R-SSC-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Sus scrofa [Reaction:R-BTA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Bos taurus [Reaction:R-CFA-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Canis familiaris [Reaction:R-RNO-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Rattus norvegicus [Reaction:R-MMU-9020273] GPX4-2 reduces 17(S)-Hp-DHA to 17(S)-HDHA - Mus musculus
output	[SimpleEntity:R-ALL-9024815] 17(S)-HDHA [cytosol] [SimpleEntity:R-ALL-111745] GSSG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol]
precedingEvent	[Reaction:R-HSA-9020275] ALOX15 oxidises DHA to 17(S)-Hp-DHA - Homo sapiens
releaseDate	2018-03-21
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9037799] Hansen, Trond Vidar, 2018-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9020273
summation	[Summation:9024473] Cytosolic phospholipid hydroperoxide glutathione peroxidase ...

Referrals

(hasEvent)	[Pathway:R-HSA-9018676] Biosynthesis of D-series resolvins
(precedingEvent)	[Reaction:R-HSA-9020282] ALOX5 oxidises 17(S)-HDHA to 7(S)-Hp-17(S)-HDHA [Reaction:R-HSA-9020264] ALOX5 oxidises 17(S)-HDHA to 4(S)-Hp-17(S)-HDHA

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