HEY1 gene expression is positively regulated by NOTCH3 and STAT1

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R-HSA-9014129
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Reaction [omitted]
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Homo sapiens
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Based on a study involving mouse and rat proteins and DNA, NOTCH3 coactivator complex positively regulates transcription of HEY1 (HRT1). Direct binding of NOTCH3 to the HEY1 gene promoter has not been demonstrated (Wang et al. 2002). STAT1 directly enhances HEY1 gene transcription induced by NICD3. In breast cancer, stromal cells secrete RNA-containing exosomes. Upon uptake of exosomes by breast cancer cells, STAT1-dependent antiviral signaling is initiated. Stromal cells also express JAG1 ligand on their surface and, in parallel to STAT1 signaling, activate NOTCH3 signaling in NOTCH3-expressing breast cancer cells. Synergistic activation of NOTCH3 and STAT1 increases breast cancer radiation resistance (Boelens et al. 2014).

Literature References
PubMed ID Title Journal Year
25417103 Exosome transfer from stromal to breast cancer cells regulates therapy resistance pathways

Boelens, MC, Wu, TJ, Nabet, BY, Xu, B, Qiu, Y, Yoon, T, Azzam, DJ, Twyman-Saint Victor, C, Wiemann, BZ, Ishwaran, H, Ter Brugge, PJ, Jonkers, J, Slingerland, J, Minn, AJ

Cell 2014
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