TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA

Stable Identifier
R-HSA-9013990
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Related Species
Influenza A virus, Rotavirus, Hepatitis B virus, Hepatitis C Virus, Human herpesvirus 1
Compartment
endosome membrane, cytosol
Synonyms
TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:activated TLR3
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TANK is ubiquitinated within TANK:K63polyUb-TRAF3:TICAM1:TLR3:viral dsRNA
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Upon stimulation by pathogen-associated inflammatory signals TANK associates with TRAF3 which may result in K63-linked ubiquitination of TANK (Gatot JC et al. 2007). How the ubiquitination of TANK contributes to the activation of TBK1 and/or IKKepsilon remains unclear.

Literature References
PubMed ID Title Journal Year
17047224 Regulation and function of IKK and IKK-related kinases

Karin, M, Hacker, H

Sci STKE 2006
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Output
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as an event of
Authored
Shamovsky, V  (2014-05-16)
Reviewed
Masci, A M  (2014-05-16)
Created
Shamovsky, V  (2017-07-26)
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