Reactome | RHOC GAPs stimulate RHOC GTPase activity

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RHOC GAPs stimulate RHOC GTPase activity Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9013125] GTPase activator activity of RHOC GAPs [cytosol]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:9013107] Orlic-Milacic, Marija, 2017-07-23
dbId	9013111
deleted	[Deleted:9768323] Deletion of instance: 194922
displayName	RHOC GAPs stimulate RHOC GTPase activity
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013106] RHOC GTPase cycle - Homo sapiens
input	[SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-HSA-5665750] RHOC:GTP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9679344] Mapping the proximity interaction network of the Rho-family GTPases reveals signalling pathways and regulatory mechanisms [LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:8980798] Direct involvement of the small GTP-binding protein Rho in lbc oncogene function [LiteratureReference:8980771] Divergence of Rho residue 43 impacts GEF activity [LiteratureReference:8980821] Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture [LiteratureReference:8980715] GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor [LiteratureReference:8980712] Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4 [LiteratureReference:8980733] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:8980756] Scambio, a novel guanine nucleotide exchange factor for Rho [LiteratureReference:9679620] ARHGAP21 is a RhoGAP for RhoA and RhoC with a role in proliferation and migration of prostate adenocarcinoma cells [LiteratureReference:9679631] Deciphering the Molecular and Functional Basis of RHOGAP Family Proteins: A SYSTEMATIC APPROACH TOWARD SELECTIVE INACTIVATION OF RHO FAMILY PROTEINS [LiteratureReference:9681442] ARAP2 effects on the actin cytoskeleton are dependent on Arf6-specific GTPase-activating-protein activity and binding to RhoA-GTP [LiteratureReference:8871052] A role of the Lowe syndrome protein OCRL in early steps of the endocytic pathway [LiteratureReference:9681483] The effect of missense mutations in the RhoGAP-homology domain on ocrl1 function [LiteratureReference:9695587] ARHGAP18: an endogenous inhibitor of angiogenesis, limiting tip formation and stabilizing junctions [LiteratureReference:9679680] Inactivation of Rho GTPases by p190 RhoGAP reduces human pancreatic cancer cell invasion and metastasis [LiteratureReference:9679693] DLC-1 suppresses non-small cell lung cancer growth and invasion by RhoGAP-dependent and independent mechanisms [LiteratureReference:8985695] Functional role for the class IX myosin myr5 in epithelial cell infection by Shigella flexneri
maxDepth	1
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	RHOC GAPs stimulate RHOC GTPase activity
orthologousEvent	[Reaction:R-SCE-9013111] RHOC GAPs stimulate RHOC GTPase activity - Saccharomyces cerevisiae [Reaction:R-SPO-9013111] RHOC GAPs stimulate RHOC GTPase activity - Schizosaccharomyces pombe [Reaction:R-GGA-9013111] RHOC GAPs stimulate RHOC GTPase activity - Gallus gallus [Reaction:R-XTR-9013111] RHOC GAPs stimulate RHOC GTPase activity - Xenopus tropicalis [Reaction:R-DRE-9013111] RHOC GAPs stimulate RHOC GTPase activity - Danio rerio [Reaction:R-SSC-9013111] RHOC GAPs stimulate RHOC GTPase activity - Sus scrofa [Reaction:R-BTA-9013111] RHOC GAPs stimulate RHOC GTPase activity - Bos taurus [Reaction:R-CFA-9013111] RHOC GAPs stimulate RHOC GTPase activity - Canis familiaris [Reaction:R-RNO-9013111] RHOC GAPs stimulate RHOC GTPase activity - Rattus norvegicus [Reaction:R-MMU-9013111] RHOC GAPs stimulate RHOC GTPase activity - Mus musculus
output	[SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-HSA-8985715] RHOC:GDP [plasma membrane]
precedingEvent	[Reaction:R-HSA-9013109] RHOC GEFs activate RHOC - Homo sapiens
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013111
summation	[Summation:9690549] The following GTPase activating proteins (GAPs) were shown t...

Referrals

(replacementInstances)	[Deleted:9768323] Deletion of instance: 194922
(hasEvent)	[Pathway:R-HSA-9013106] RHOC GTPase cycle

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