Reactome | RHOC GEFs activate RHOC

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RHOC GEFs activate RHOC Show undefined attributes

authored	[InstanceEdit:9695572] Orlic-Milacic, Marija, 2020-07-14
catalystActivity	[CatalystActivity:9013120] guanyl-nucleotide exchange factor activity of RHOC GEFs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9013107] Orlic-Milacic, Marija, 2017-07-23
dbId	9013109
deleted	[Deleted:9768327] Deletion of instance: 194913
displayName	RHOC GEFs activate RHOC
edited	[InstanceEdit:9716798] Orlic-Milacic, Marija, 2021-02-25
eventOf	[Pathway:R-HSA-9013106] RHOC GTPase cycle - Homo sapiens
followingEvent	[Reaction:R-HSA-9013110] RHOC binds effectors at the plasma membrane - Homo sapiens [Reaction:R-HSA-9013111] RHOC GAPs stimulate RHOC GTPase activity - Homo sapiens [BlackBoxEvent:R-HSA-9714363] RHOC translocates to the endoplasmic reticulum membrane - Homo sapiens [Reaction:R-HSA-9013108] GDIs block activation of RHOC - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-HSA-8985715] RHOC:GDP [plasma membrane]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:9644217] Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins [LiteratureReference:8980798] Direct involvement of the small GTP-binding protein Rho in lbc oncogene function [LiteratureReference:8980771] Divergence of Rho residue 43 impacts GEF activity [LiteratureReference:8980821] Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture [LiteratureReference:8980715] GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor [LiteratureReference:8980712] Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4 [LiteratureReference:8980733] Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) [LiteratureReference:8980837] Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 [LiteratureReference:8980756] Scambio, a novel guanine nucleotide exchange factor for Rho [LiteratureReference:8980763] XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	RHOC GEFs activate RHOC
orthologousEvent	[Reaction:R-GGA-9013109] RHOC GEFs activate RHOC - Gallus gallus [Reaction:R-XTR-9013109] RHOC GEFs activate RHOC - Xenopus tropicalis [Reaction:R-DRE-9013109] RHOC GEFs activate RHOC - Danio rerio [Reaction:R-SSC-9013109] RHOC GEFs activate RHOC - Sus scrofa [Reaction:R-BTA-9013109] RHOC GEFs activate RHOC - Bos taurus [Reaction:R-CFA-9013109] RHOC GEFs activate RHOC - Canis familiaris [Reaction:R-RNO-9013109] RHOC GEFs activate RHOC - Rattus norvegicus [Reaction:R-MMU-9013109] RHOC GEFs activate RHOC - Mus musculus
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-HSA-5665750] RHOC:GTP [plasma membrane]
releaseDate	2021-03-23
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9714226] Fort, Philippe, 2021-02-05
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-9013109
summation	[Summation:9690524] The following guanine nucleotide exchange factors (GEFs) wer...

Referrals

(replacementInstances)	[Deleted:9768327] Deletion of instance: 194913
(precedingEvent)	[Reaction:R-HSA-9013110] RHOC binds effectors at the plasma membrane [Reaction:R-HSA-9013111] RHOC GAPs stimulate RHOC GTPase activity [BlackBoxEvent:R-HSA-9714363] RHOC translocates to the endoplasmic reticulum membrane [Reaction:R-HSA-9013108] GDIs block activation of RHOC
(hasEvent)	[Pathway:R-HSA-9013106] RHOC GTPase cycle

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