Reactome | RHOC GEFs activate RHOC

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RHOC GEFs activate RHOC Show undefined attributes

catalystActivity	[CatalystActivity:9967241] guanyl-nucleotide exchange factor activity of RHOC GEFs [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:9864362] Wright, Adam, 2024-03-07
dbId	9967243
displayName	RHOC GEFs activate RHOC
eventOf	[Pathway:R-MMU-9013106] RHOC GTPase cycle - Mus musculus
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-MMU-9013110] RHOC binds effectors at the plasma membrane - Mus musculus [Reaction:R-MMU-9013111] RHOC GAPs stimulate RHOC GTPase activity - Mus musculus [BlackBoxEvent:R-MMU-9714363] RHOC translocates to the endoplasmic reticulum membrane - Mus musculus [Reaction:R-MMU-9013108] GDIs block activation of RHOC - Mus musculus
inferredFrom	[Reaction:R-HSA-9013109] RHOC GEFs activate RHOC - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [Complex:R-MMU-8985715] RHOC:GDP [plasma membrane]
isInDisease	false
isInferred	true
name	RHOC GEFs activate RHOC
output	[SimpleEntity:R-ALL-29420] GDP [cytosol] [Complex:R-MMU-5665750] RHOC:GTP [plasma membrane]
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-9013109
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-9013106] RHOC GTPase cycle
(precedingEvent)	[Reaction:R-MMU-9013110] RHOC binds effectors at the plasma membrane [Reaction:R-MMU-9013111] RHOC GAPs stimulate RHOC GTPase activity [BlackBoxEvent:R-MMU-9714363] RHOC translocates to the endoplasmic reticulum membrane [Reaction:R-MMU-9013108] GDIs block activation of RHOC
(inferredTo)	[Reaction:R-HSA-9013109] RHOC GEFs activate RHOC