RHOC GEFs activate RHOC

Stable Identifier
Reaction [transition]
Homo sapiens
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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOC and catalyze GDP to GTP exchange on RHOC, resulting in formation of the active RHOC:GTP complex:
AKAP13 (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
ARHGEF10 (Mohl et al. 2006)
ARHGEF10L (Winkler et al. 2005)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF17 (Mitin et al. 2012)
ARHGEF25 (Sloan et al. 2012)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF40 (Curtis et al. 2004)
MCF2 (Sloan et al. 2012; Jaiswal et al. 2013)
MCF2L (Sloan et al. 2012; Jaiswal et al. 2013)
PREX1 (Jaiswal et al. 2013)
VAV2 (Sloan et al. 2012; Jaiswal et al. 2013)

The following GEFs do not act on RHOC:
ARHGEF3 (Arthur et al. 2002; Sloan et al. 2012)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
ITSN1 (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)

Literature References
PubMed ID Title Journal Year
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Wang, Z, Kumamoto, Y, Wang, P, Gan, X, Lehmann, D, Smrcka, AV, Cohn, L, Iwasaki, A, Li, L, Wu, D

J. Biol. Chem. 2009
15107133 Scambio, a novel guanine nucleotide exchange factor for Rho

Curtis, C, Hemmeryckx, B, Haataja, L, Senadheera, D, Groffen, J, Heisterkamp, N

Mol. Cancer 2004
16896804 Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture

Mohl, M, Winkler, S, Wieland, T, Lutz, S

Naunyn Schmiedebergs Arch. Pharmacol. 2006
22673745 Divergence of Rho residue 43 impacts GEF activity

Sloan, CM, Quinn, CV, Peters, JP, Farley, J, Goetzinger, C, Wernli, M, DeMali, KA, Ellerbroek, SM

Small GTPases 2012
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Jaiswal, M, Dvorsky, R, Ahmadian, MR

J. Biol. Chem. 2013
7721814 Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

Zheng, Y, Olson, MF, Hall, A, Cerione, RA, Toksoz, D

J. Biol. Chem. 1995
21454492 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Jaiswal, M, Gremer, L, Dvorsky, R, Haeusler, LC, Cirstea, IC, Uhlenbrock, K, Ahmadian, MR

J. Biol. Chem. 2011
12221096 XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

Arthur, WT, Ellerbroek, SM, Der, CJ, Burridge, K, Wennerberg, K

J. Biol. Chem. 2002
16112081 GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor

Winkler, S, Mohl, M, Wieland, T, Lutz, S

Biochem. Biophys. Res. Commun. 2005
22911862 Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4

Mitin, N, Rossman, KL, Der, CJ

PLoS ONE 2012
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOC GEFs [cytosol]

Orthologous Events
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