Reactome | RHOC GEFs activate RHOC

RHOC GEFs activate RHOC

Stable Identifier

R-HSA-9013109

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol, plasma membrane

ReviewStatus

5/5

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The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOC and catalyze GDP to GTP exchange on RHOC, resulting in formation of the active RHOC:GTP complex:
AKAP13 (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
ARHGEF10 (Mohl et al. 2006)
ARHGEF10L (Winkler et al. 2005)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF17 (Mitin et al. 2012)
ARHGEF25 (Sloan et al. 2012)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF40 (Curtis et al. 2004)
MCF2 (Sloan et al. 2012; Jaiswal et al. 2013)
MCF2L (Sloan et al. 2012; Jaiswal et al. 2013)
PREX1 (Jaiswal et al. 2013)
VAV2 (Sloan et al. 2012; Jaiswal et al. 2013)

The following GEFs do not act on RHOC:
ARHGEF3 (Arthur et al. 2002; Sloan et al. 2012)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
ITSN1 (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)

Literature References

PubMed ID	Title	Journal	Year
15107133	Scambio, a novel guanine nucleotide exchange factor for Rho Curtis, C, Hemmeryckx, B, Haataja, L, Senadheera, D, Groffen, J, Heisterkamp, N	Mol. Cancer	2004
19713215	Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5 Wang, Z, Kumamoto, Y, Wang, P, Gan, X, Lehmann, D, Smrcka, AV, Cohn, L, Iwasaki, A, Li, L, Wu, D	J. Biol. Chem.	2009
16896804	Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture Mohl, M, Winkler, S, Wieland, T, Lutz, S	Naunyn Schmiedebergs Arch. Pharmacol.	2006
22673745	Divergence of Rho residue 43 impacts GEF activity Sloan, CM, Quinn, CV, Peters, JP, Farley, J, Goetzinger, C, Wernli, M, DeMali, KA, Ellerbroek, SM	Small GTPases	2012
23255595	Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins Jaiswal, M, Dvorsky, R, Ahmadian, MR	J. Biol. Chem.	2013
7721814	Direct involvement of the small GTP-binding protein Rho in lbc oncogene function Zheng, Y, Olson, MF, Hall, A, Cerione, RA, Toksoz, D	J. Biol. Chem.	1995
21454492	Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG) Jaiswal, M, Gremer, L, Dvorsky, R, Haeusler, LC, Cirstea, IC, Uhlenbrock, K, Ahmadian, MR	J. Biol. Chem.	2011
12221096	XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC Arthur, WT, Ellerbroek, SM, Der, CJ, Burridge, K, Wennerberg, K	J. Biol. Chem.	2002
16112081	GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor Winkler, S, Mohl, M, Wieland, T, Lutz, S	Biochem. Biophys. Res. Commun.	2005
22911862	Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4 Mitin, N, Rossman, KL, Der, CJ	PLoS ONE	2012