RHOC GEFs activate RHOC

Stable Identifier
Reaction [transition]
Homo sapiens
Locations in the PathwayBrowser
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

The following guanine nucleotide exchange factors (GEFs) were shown to bind RHOC and catalyze GDP to GTP exchange on RHOC, resulting in formation of the active RHOC:GTP complex:
AKAP13 (Zheng et al. 1995)
ARHGEF1 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF5 (Wang et al. 2009)
ARHGEF10 (Mohl et al. 2006)
ARHGEF10L (Winkler et al. 2005)
ARHGEF11 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF12 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF17 (Mitin et al. 2012)
ARHGEF25 (Sloan et al. 2012)
ARHGEF28 (Jaiswal et al. 2011; Jaiswal et al. 2013)
ARHGEF40 (Curtis et al. 2004)
MCF2 (Sloan et al. 2012; Jaiswal et al. 2013)
MCF2L (Sloan et al. 2012; Jaiswal et al. 2013)
PREX1 (Jaiswal et al. 2013)
VAV2 (Sloan et al. 2012; Jaiswal et al. 2013)

The following GEFs do not act on RHOC:
ARHGEF3 (Arthur et al. 2002; Sloan et al. 2012)
ARHGEF4 (Jaiswal et al. 2013)
ARHGEF9 (Jaiswal et al. 2013)
DNMBP (Jaiswal et al. 2013)
ITSN1 (Jaiswal et al. 2013)
TIAM1 (Jaiswal et al. 2013)

Literature References
PubMed ID Title Journal Year
15107133 Scambio, a novel guanine nucleotide exchange factor for Rho

Groffen, J, Heisterkamp, N, Senadheera, D, Haataja, L, Curtis, C, Hemmeryckx, B

Mol. Cancer 2004
19713215 Regulation of immature dendritic cell migration by RhoA guanine nucleotide exchange factor Arhgef5

Lehmann, D, Gan, X, Wang, P, Wang, Z, Li, L, Smrcka, AV, Iwasaki, A, Wu, D, Cohn, L, Kumamoto, Y

J. Biol. Chem. 2009
16896804 Gef10--the third member of a Rho-specific guanine nucleotide exchange factor subfamily with unusual protein architecture

Winkler, S, Mohl, M, Lutz, S, Wieland, T

Naunyn Schmiedebergs Arch. Pharmacol. 2006
22673745 Divergence of Rho residue 43 impacts GEF activity

Quinn, CV, Goetzinger, C, Farley, J, Sloan, CM, Ellerbroek, SM, Peters, JP, Wernli, M, DeMali, KA

Small GTPases 2012
23255595 Deciphering the molecular and functional basis of Dbl family proteins: a novel systematic approach toward classification of selective activation of the Rho family proteins

Ahmadian, MR, Jaiswal, M, Dvorsky, R

J. Biol. Chem. 2013
7721814 Direct involvement of the small GTP-binding protein Rho in lbc oncogene function

Olson, MF, Cerione, RA, Toksoz, D, Hall, A, Zheng, Y

J. Biol. Chem. 1995
21454492 Mechanistic insights into specificity, activity, and regulatory elements of the regulator of G-protein signaling (RGS)-containing Rho-specific guanine nucleotide exchange factors (GEFs) p115, PDZ-RhoGEF (PRG), and leukemia-associated RhoGEF (LARG)

Cirstea, IC, Ahmadian, MR, Uhlenbrock, K, Jaiswal, M, Dvorsky, R, Gremer, L, Haeusler, LC

J. Biol. Chem. 2011
12221096 XPLN, a guanine nucleotide exchange factor for RhoA and RhoB, but not RhoC

Der, CJ, Burridge, K, Ellerbroek, SM, Arthur, WT, Wennerberg, K

J. Biol. Chem. 2002
16112081 GrinchGEF--a novel Rho-specific guanine nucleotide exchange factor

Winkler, S, Mohl, M, Lutz, S, Wieland, T

Biochem. Biophys. Res. Commun. 2005
22911862 Identification of a novel actin-binding domain within the Rho guanine nucleotide exchange factor TEM4

Der, CJ, Rossman, KL, Mitin, N

PLoS ONE 2012
Catalyst Activity

guanyl-nucleotide exchange factor activity of RHOC GEFs [cytosol]

Orthologous Events
Cite Us!