Reactome | IL10RB binds TYK2

Schema > Reaction > Entries

IL10RB binds TYK2 Show undefined attributes

authored	[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
dbId	8987223
displayName	IL10RB binds TYK2
edited	[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
eventOf	[Pathway:R-HSA-8854691] Interleukin-20 family signaling - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Homo sapiens [Reaction:R-HSA-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Homo sapiens [Reaction:R-HSA-8986480] IL26:IL20RA:JAK1 binds IL10RB:TYK2 - Homo sapiens [Reaction:R-HSA-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1 - Homo sapiens
input	[EntityWithAccessionedSequence:R-HSA-448423] IL10RB [plasma membrane] [EntityWithAccessionedSequence:R-HSA-877348] TYK2 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8987085] The molecular basis of IL-10 function: from receptor structure to the onset of signaling [LiteratureReference:8987116] Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2
maxDepth	1
modified	[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name	IL10RB binds TYK2
orthologousEvent	[Reaction:R-CFA-8987223] IL10RB binds TYK2 - Canis familiaris [Reaction:R-GGA-8987223] IL10RB binds TYK2 - Gallus gallus [Reaction:R-XTR-8987223] IL10RB binds TYK2 - Xenopus tropicalis [Reaction:R-DRE-8987223] IL10RB binds TYK2 - Danio rerio [Reaction:R-SSC-8987223] IL10RB binds TYK2 - Sus scrofa [Reaction:R-BTA-8987223] IL10RB binds TYK2 - Bos taurus [Reaction:R-RNO-8987223] IL10RB binds TYK2 - Rattus norvegicus [Reaction:R-MMU-8987223] IL10RB binds TYK2 - Mus musculus
output	[Complex:R-HSA-6784360] IL10RB:TYK2 [plasma membrane]
releaseDate	2017-12-13
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8987223
summation	[Summation:8987081] Interleukin-10 receptor subunit beta (IL10RB, IL10R2) binds ...

Referrals

(precedingEvent)	[BlackBoxEvent:R-HSA-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 [Reaction:R-HSA-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 [Reaction:R-HSA-8986480] IL26:IL20RA:JAK1 binds IL10RB:TYK2 [Reaction:R-HSA-448661] IFNL1 binds IL10RB:TYK2 and IFNLR1:JAK1
(hasEvent)	[Pathway:R-HSA-8854691] Interleukin-20 family signaling