IL10RB binds TYK2

Stable Identifier
Homo sapiens
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Interleukin-10 receptor subunit beta (IL10RB, IL10R2) binds non-receptor tyrosine-protein kinase TYK2 (TYK2). Interleukin-10 receptor subunit alpha (IL10RA, IL10R1) and IL10RB extracellular domains bind Interleukin-10 (IL10), their intracellular domains are constitutively associated with Tyrosine-protein kinase JAK1 (JAK1) and TYK2 kinases, respectively (Finbloom & Winestock 1995, Ho et al. 1995).
The function of the IL10RB Intracellular domain is to provide a docking site for TYK2, which provides a generic activation signal that can be used to activate signaling pathways associated with the four different Receptor 1 chains, Interleukin-20 receptor subunit alpha (IL20RA), Interleukin-22 receptor subunit alpha-1 (IL22RA1), Interferon lambda receptor 1 (IFNLR1) and Interleukin-10 receptor subunit alpha (IL10RA).

Literature References
PubMed ID Title Journal Year
14764663 Cutting edge: IL-26 signals through a novel receptor complex composed of IL-20 receptor 1 and IL-10 receptor 2

Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV

J. Immunol. 2004
25004819 The molecular basis of IL-10 function: from receptor structure to the onset of signaling

Walter, MR

Curr. Top. Microbiol. Immunol. 2014
Orthologous Events
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