Interleukin-10 receptor subunit beta (IL10RB, IL10R2) binds non-receptor tyrosine-protein kinase TYK2 (TYK2). Interleukin-10 receptor subunit alpha (IL10RA, IL10R1) and IL10RB extracellular domains bind Interleukin-10 (IL10), their intracellular domains are constitutively associated with Tyrosine-protein kinase JAK1 (JAK1) and TYK2 kinases, respectively (Finbloom & Winestock 1995, Ho et al. 1995).The function of the IL10RB Intracellular domain is to provide a docking site for TYK2, which provides a generic activation signal that can be used to activate signaling pathways associated with the four different Receptor 1 chains, Interleukin-20 receptor subunit alpha (IL20RA), Interleukin-22 receptor subunit alpha-1 (IL22RA1), Interferon lambda receptor 1 (IFNLR1) and Interleukin-10 receptor subunit alpha (IL10RA).
Baurin, VV, Lewis-Antes, A, Shah, NK, Dumoutier, L, Zdanov, A, Anantha, S, Smirnov, SV, Sheikh, F, Renauld, JC, Dickensheets, H, Donnelly, RP, Kotenko, SV
Walter, MR
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