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Schema
>
BlackBoxEvent
>
Entries
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
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authored
[InstanceEdit:8982160] Duenas, Corina, 2017-03-16
category
uncertain
compartment
[Compartment:70101] cytosol
[Compartment:984] extracellular region
[Compartment:876] plasma membrane
created
[InstanceEdit:8987035] Duenas, Corina, 2017-05-05
dbId
8987105
displayName
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
edited
[InstanceEdit:9028437] Jupe, Steve, 2017-11-07
eventOf
[Pathway:R-HSA-8854691] Interleukin-20 family signaling - Homo sapiens
input
[DefinedSet:R-HSA-448648] IFNL2,IFNL3 [extracellular region]
[Complex:R-HSA-8987216] IFNLR1:JAK1 [plasma membrane]
[Complex:R-HSA-6784360] IL10RB:TYK2 [plasma membrane]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8987128] Role of the interleukin (IL)-28 receptor tyrosine residues for antiviral and antiproliferative activity of IL-29/interferon-lambda 1: similarities with type I interferon signaling (Dumoutier et al. ).
[LiteratureReference:9011064] Interferon-lambda is functionally an interferon but structurally related to the interleukin-10 family
maxDepth
1
modified
[InstanceEdit:10732209] Weiser, Joel, 2026-03-16
name
IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1
IFNL2,IFNL3 binds IL10RB:TYK2 and IFNLR1:JAK1 receptor complex
IL28 binds to IL28 receptor complex
IFNL2, INFL3 binds IFNLR1:IL10RB receptor complex
orthologousEvent
[BlackBoxEvent:R-GGA-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Gallus gallus
[BlackBoxEvent:R-XTR-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Xenopus tropicalis
[BlackBoxEvent:R-SSC-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Sus scrofa
[BlackBoxEvent:R-BTA-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Bos taurus
[BlackBoxEvent:R-CFA-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Canis familiaris
[BlackBoxEvent:R-RNO-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Rattus norvegicus
[BlackBoxEvent:R-MMU-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Mus musculus
output
[Complex:R-HSA-8987146] IFNL2,IFNL3:IFNLR1:JAK1:IL10RB:TYK2 [plasma membrane]
precedingEvent
[Reaction:R-HSA-8987120] JAK1 binds IFNLR1 - Homo sapiens
[Reaction:R-HSA-8987223] IL10RB binds TYK2 - Homo sapiens
releaseDate
2017-12-13
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:9029252] Datta, Sandip K, 2017-11-15
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8987105
summation
[Summation:8987260] Interferon lambda-1 (IFNL1) binds Interleukin-10 receptor su...
Referrals
(hasEvent)
[Pathway:R-HSA-8854691] Interleukin-20 family signaling
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