Reactome | IL10RB binds TYK2

Schema > Reaction > Entries

IL10RB binds TYK2 Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10208252
displayName	IL10RB binds TYK2
eventOf	[Pathway:R-RNO-8854691] Interleukin-20 family signaling - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 - Rattus norvegicus [Reaction:R-RNO-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2 - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8987223] IL10RB binds TYK2 - Homo sapiens
input	[EntityWithAccessionedSequence:R-RNO-448423] Il10rb [plasma membrane] [EntityWithAccessionedSequence:R-RNO-877348] TYK2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	IL10RB binds TYK2
output	[Complex:R-RNO-6784360] IL10RB:TYK2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8987223
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-8854691] Interleukin-20 family signaling
(precedingEvent)	[BlackBoxEvent:R-RNO-8987105] IFNL2,IFNL3 bind IL10RB:TYK2 and IFNLR1:JAK1 [Reaction:R-RNO-8854645] IL22:IL22RA1:JAK1 binds IL10RB:TYK2
(inferredTo)	[Reaction:R-HSA-8987223] IL10RB binds TYK2