G-Protein Coupled Receptors (GPCR) sense extracellular signa...

created [InstanceEdit:8964250] Varusai, Thawfeek, 2017-02-16
dbId 8964245
displayName G-Protein Coupled Receptors (GPCR) sense extracellular signa...
modified [InstanceEdit:8982300] Varusai, Thawfeek, 2017-03-17
schemaClass Summation
text G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind directly to the non-receptor Tyrosine-protein kinase BTK. This binding breaks intramolecular interactions in BTK thereby making the kinase domain available for substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.
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