Reactome | BTK in active Gq-BTK complex is activated

BTK in active Gq-BTK complex is activated

Stable Identifier

R-HSA-8964284

Type

Reaction [transition]

Species

Homo sapiens

Compartment

plasma membrane

ReviewStatus

5/5

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BTK in active Gq-BTK complex is activated

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G-Protein Coupled Receptors (GPCR) sense extracellular signals and activate different Guanine nucleotide binding proteins. Upon activation, the Guanine nucleotide-binding protein G(q) subunit alpha class (GNAQ/GNA11/GNA14/GNA15) can bind directly to the non-receptor Tyrosine-protein kinase BTK. This binding breaks intramolecular interactions in BTK thereby making the kinase domain available for substrates. Physiologically, BTK plays a key role in B lymphocyte development, differentiation and signalling.

Literature References

PubMed ID	Title	Journal	Year
9770463	Identification of the binding site for Gqalpha on its effector Bruton's tyrosine kinase Ma, YC, Huang, XY	Proc. Natl. Acad. Sci. U.S.A.	1998
9305846	Direct stimulation of Bruton's tyrosine kinase by G(q)-protein alpha-subunit Bence, K, Ma, W, Kozasa, T, Huang, XY	Nature	1997
11742120	Competing modes of self-association in the regulatory domains of Bruton's tyrosine kinase: intramolecular contact versus asymmetric homodimerization Laederach, A, Cradic, KW, Brazin, KN, Zamoon, J, Fulton, DB, Huang, XY, Andreotti, AH	Protein Sci.	2002