Reactome | PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

Stable Identifier

R-HSA-8961665

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

nucleoplasm

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PCNA gene expression is stimulated by E2F1 and repressed by the DREAM complex

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E2F1 directly stimulates transcription of the PCNA gene, which encodes the proliferating cell nuclear antigen, a component of the DNA polymerase complex involved in eukaryotic DNA replication (DeGregori et al. 1995, Li et al. 2003).
The PCNA gene transcription is directly repressed by the DREAM complex (Litovchick et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
8050359	Developmental control of a G1-S transcriptional program in Drosophila Duronio, RJ, O'Farrell, PH	Development	1994
7623816	Cellular targets for activation by the E2F1 transcription factor include DNA synthesis- and G1/S-regulatory genes DeGregori, J, Kowalik, T, Nevins, JR	Mol Cell Biol	1995
12782299	An E2F site in the 5'-promoter region contributes to serum-dependent up-regulation of the human proliferating cell nuclear antigen gene Li, YY, Wang, L, Lu, CD	FEBS Lett.	2003