Reactome | NEDD8 and UBD bind NUB1 and the 26S proteasome

Schema > Reaction > Entries

NEDD8 and UBD bind NUB1 and the 26S proteasome Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8956141] Rothfels, Karen, 2017-01-16
dbId	8956140
displayName	NEDD8 and UBD bind NUB1 and the 26S proteasome
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
followingEvent	[BlackBoxEvent:R-HSA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Homo sapiens
input	[Complex:R-HSA-68819] 26S proteasome [cytosol] [DefinedSet:R-HSA-8956136] NEDD8,UBD [cytosol] [DefinedSet:R-HSA-8956132] NUB1 [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8956178] NUB1, a NEDD8-interacting protein, is induced by interferon and down-regulates the NEDD8 expression [LiteratureReference:8956167] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 [LiteratureReference:8956161] NEDD8 ultimate buster-1L interacts with the ubiquitin-like protein FAT10 and accelerates its degradation [LiteratureReference:8956170] The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 [LiteratureReference:8956157] Interaction of NUB1 with the proteasome subunit S5a [LiteratureReference:8956153] Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy [LiteratureReference:8956152] FAT10ylation as a signal for proteasomal degradation [LiteratureReference:8956174] Regulation of the NEDD8 conjugation system by a splicing variant, NUB1L
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	NEDD8 and UBD bind NUB1 and the 26S proteasome
negativePrecedingEvent	[NegativePrecedingEvent:9767188] Futile Cycle: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent	[Reaction:R-DME-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Drosophila melanogaster [Reaction:R-GGA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Gallus gallus [Reaction:R-XTR-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Xenopus tropicalis [Reaction:R-SSC-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Sus scrofa [Reaction:R-BTA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Bos taurus [Reaction:R-CFA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Canis familiaris [Reaction:R-RNO-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Rattus norvegicus [Reaction:R-MMU-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Mus musculus
output	[Complex:R-HSA-8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol]
precedingEvent	[Reaction:R-HSA-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Homo sapiens [Reaction:R-HSA-8951644] Release of mature NEDD8 - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8956140
summation	[Summation:8956182] NEDD8 ultimate buster 1 (NUB1) is a negative regulator of th...

Referrals

(hasEvent)	[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)	[BlackBoxEvent:R-HSA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Cite Us!