Reactome | NEDD8 and UBD bind NUB1 and the 26S proteasome

Schema > Reaction > Entries

NEDD8 and UBD bind NUB1 and the 26S proteasome Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:9984900] Weiser, Joel, 2026-03-16
dbId	10084152
displayName	NEDD8 and UBD bind NUB1 and the 26S proteasome
eventOf	[Pathway:R-MMU-8951664] Neddylation - Mus musculus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-MMU-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Mus musculus
inferredFrom	[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Homo sapiens
input	[Complex:R-MMU-68819] 26S proteasome [cytosol] [DefinedSet:R-MMU-8956136] NEDD8,UBD [cytosol] [EntityWithAccessionedSequence:R-MMU-8956129] Nub1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	NEDD8 and UBD bind NUB1 and the 26S proteasome
output	[Complex:R-MMU-8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol]
precedingEvent	[Reaction:R-MMU-8956040] COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes - Mus musculus [Reaction:R-MMU-8951644] Release of mature NEDD8 - Mus musculus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48892] Mus musculus
stId	R-MMU-8956140
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-MMU-8951664] Neddylation
(precedingEvent)	[BlackBoxEvent:R-MMU-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
(inferredTo)	[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome

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