Reactome | 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates

Schema > BlackBoxEvent > Entries

26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates Show undefined attributes

authored	[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category	omitted
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:8956183] Rothfels, Karen, 2017-01-17
dbId	8956184
displayName	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
edited	[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf	[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input	[Complex:R-HSA-8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8956167] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1 [LiteratureReference:8956157] Interaction of NUB1 with the proteasome subunit S5a [LiteratureReference:8956170] The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10 [LiteratureReference:8956153] Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy [LiteratureReference:8956152] FAT10ylation as a signal for proteasomal degradation
maxDepth	1
modified	[InstanceEdit:10829237] Weiser, Joel, 2026-03-16
name	26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent	[BlackBoxEvent:R-DME-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Drosophila melanogaster [BlackBoxEvent:R-GGA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Gallus gallus [BlackBoxEvent:R-XTR-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Xenopus tropicalis [BlackBoxEvent:R-SSC-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Sus scrofa [BlackBoxEvent:R-BTA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Bos taurus [BlackBoxEvent:R-CFA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Canis familiaris [BlackBoxEvent:R-RNO-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Rattus norvegicus [BlackBoxEvent:R-MMU-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Mus musculus
output	[Complex:R-HSA-68819] 26S proteasome [cytosol] [DefinedSet:R-HSA-8956132] NUB1 [cytosol]
precedingEvent	[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass	BlackBoxEvent
species	[Species:48887] Homo sapiens
stId	R-HSA-8956184
summation	[Summation:8956180] NUB1 mediates the 26S proteasome-dependent degradation of NE...

Referrals

(hasEvent)

[Pathway:R-HSA-8951664] Neddylation

(precedingEvent)

[NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767169] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767202] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767188] Futile Cycle: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates