Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Schema
>
BlackBoxEvent
>
Entries
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
Show undefined attributes
Go to Details
authored
[InstanceEdit:8952019] Rothfels, Karen, 2016-12-12
category
omitted
compartment
[Compartment:70101] cytosol
created
[InstanceEdit:8956183] Rothfels, Karen, 2017-01-17
dbId
8956184
displayName
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
edited
[InstanceEdit:8952049] Rothfels, Karen, 2016-12-12
eventOf
[Pathway:R-HSA-8951664] Neddylation - Homo sapiens
input
[Complex:R-HSA-8956137] NEDD8,UBD:NUB1:26S proteasome [cytosol]
isChimeric
false
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8956167] Targeting of NEDD8 and its conjugates for proteasomal degradation by NUB1
[LiteratureReference:8956157] Interaction of NUB1 with the proteasome subunit S5a
[LiteratureReference:8956170] The UBA domains of NUB1L are required for binding but not for accelerated degradation of the ubiquitin-like modifier FAT10
[LiteratureReference:8956153] Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy
[LiteratureReference:8956152] FAT10ylation as a signal for proteasomal degradation
modified
[InstanceEdit:10655440] Wright, Adam, 2024-03-08
name
26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
orthologousEvent
[BlackBoxEvent:R-DME-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Drosophila melanogaster
[BlackBoxEvent:R-SSC-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Sus scrofa
[BlackBoxEvent:R-BTA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Bos taurus
[BlackBoxEvent:R-CFA-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Canis familiaris
[BlackBoxEvent:R-RNO-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Rattus norvegicus
[BlackBoxEvent:R-MMU-8956184] 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates - Mus musculus
output
[Complex:R-HSA-68819] 26S proteasome [cytosol]
[DefinedSet:R-HSA-8956132] NUB1 [cytosol]
precedingEvent
[Reaction:R-HSA-8956140] NEDD8 and UBD bind NUB1 and the 26S proteasome - Homo sapiens
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8979124] Pick, Elah, 2017-02-21
schemaClass
BlackBoxEvent
species
[Species:48887] Homo sapiens
stId
R-HSA-8956184
summation
[Summation:8956180] NUB1 mediates the 26S proteasome-dependent degradation of NE...
Referrals
(hasEvent)
[Pathway:R-HSA-8951664] Neddylation
(precedingEvent)
[NegativePrecedingEvent:9767199] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767169] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767202] Abundant Molecules: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
[NegativePrecedingEvent:9767188] Futile Cycle: 26S- and NUB1-mediated degradation of NEDD8, UBD and their conjugates
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text