Reactome | Mitochondrial calcium ion transport

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Mitochondrial calcium ion transport Show undefined attributes

authored	[InstanceEdit:8949206] May, Bruce, 2016-11-21
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
dbId	8949215
displayName	Mitochondrial calcium ion transport
doi	10.3180/R-HSA-8949215.1
edited	[InstanceEdit:8949206] May, Bruce, 2016-11-21
eventOf	[TopLevelPathway:R-HSA-382551] Transport of small molecules - Homo sapiens
goBiologicalProcess	[GO_BiologicalProcess:22537] mitochondrial calcium ion transmembrane transport
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-HSA-8949145] VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space - Homo sapiens [Pathway:R-HSA-8949664] Processing of SMDT1 - Homo sapiens [Reaction:R-HSA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Homo sapiens [Reaction:R-HSA-8949688] SLC8B1 (NCLX) exchanges sodium (mitochondrial intermembrane space) for calcium (mitochondrial matrix) - Homo sapiens [Reaction:R-HSA-8949687] LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) - Homo sapiens [Reaction:R-HSA-8949703] SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) - Homo sapiens
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8949211] The mitochondrial Ca(2+) uniporter complex [LiteratureReference:8949210] Structure and function of the mitochondrial calcium uniporter complex [LiteratureReference:8949219] Calcium uptake mechanisms of mitochondria [LiteratureReference:8949157] The mitochondrial calcium uniporter complex: molecular components, structure and physiopathological implications [LiteratureReference:8949213] Mitochondria as sensors and regulators of calcium signalling [LiteratureReference:8951464] Enjoy the Trip: Calcium in Mitochondria Back and Forth [LiteratureReference:8951476] After half a century mitochondrial calcium in- and efflux machineries reveal themselves
maxDepth	3
modified	[InstanceEdit:11080360] Weiser, Joel, 2026-03-16
name	Mitochondrial calcium ion transport
orthologousEvent	[Pathway:R-SCE-8949215] Mitochondrial calcium ion transport - Saccharomyces cerevisiae [Pathway:R-SPO-8949215] Mitochondrial calcium ion transport - Schizosaccharomyces pombe [Pathway:R-DDI-8949215] Mitochondrial calcium ion transport - Dictyostelium discoideum [Pathway:R-CEL-8949215] Mitochondrial calcium ion transport - Caenorhabditis elegans [Pathway:R-DME-8949215] Mitochondrial calcium ion transport - Drosophila melanogaster [Pathway:R-GGA-8949215] Mitochondrial calcium ion transport - Gallus gallus [Pathway:R-XTR-8949215] Mitochondrial calcium ion transport - Xenopus tropicalis [Pathway:R-DRE-8949215] Mitochondrial calcium ion transport - Danio rerio [Pathway:R-SSC-8949215] Mitochondrial calcium ion transport - Sus scrofa [Pathway:R-BTA-8949215] Mitochondrial calcium ion transport - Bos taurus [Pathway:R-CFA-8949215] Mitochondrial calcium ion transport - Canis familiaris [Pathway:R-RNO-8949215] Mitochondrial calcium ion transport - Rattus norvegicus [Pathway:R-MMU-8949215] Mitochondrial calcium ion transport - Mus musculus
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
schemaClass	Pathway
species	[Species:48887] Homo sapiens
stId	R-HSA-8949215
summation	[Summation:8953482] Divalent calcium ions (Ca2+) are transported from the cytoso...

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[TopLevelPathway:R-HSA-382551] Transport of small molecules

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