Reactome | LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Schema > Reaction > Entries

LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) Show undefined attributes

authored	[InstanceEdit:8949686] May, Bruce, 2016-11-28
catalystActivity	[CatalystActivity:8949691] calcium:proton antiporter activity of LETM1 hexamer [mitochondrial inner membrane]
catalystActivityReference	[CatalystActivityReference:9644043] calcium:proton antiporter activity of LETM1 hexamer [mitochondrial inner membrane] Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949699] May, Bruce, 2016-11-28
crossReference	[DatabaseIdentifier:12668146] RHEA:72199
dbId	8949687
displayName	LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
edited	[InstanceEdit:8949686] May, Bruce, 2016-11-28
eventOf	[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport - Homo sapiens
followingEvent	[Reaction:R-HSA-8949703] SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space) - Homo sapiens
inferredFrom	[Reaction:R-MMU-8951834] Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix) - Mus musculus
input	[SimpleEntity:R-ALL-8949220] Ca2+ [mitochondrial matrix] 2 × [SimpleEntity:R-ALL-163953] H+ [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8949713] Characterization of the mitochondrial protein LETM1, which maintains the mitochondrial tubular shapes and interacts with the AAA-ATPase BCS1L [LiteratureReference:8949714] Letm1, the mitochondrial Ca2+/H+ antiporter, is essential for normal glucose metabolism and alters brain function in Wolf-Hirschhorn syndrome [LiteratureReference:8949692] Leucine zipper-EF-hand containing transmembrane protein 1 (LETM1) forms a Ca(2+)/H(+) antiporter [LiteratureReference:8951452] LETM1-dependent mitochondrial Ca2+ flux modulates cellular bioenergetics and proliferation [LiteratureReference:8951458] NCLX protein, but not LETM1, mediates mitochondrial Ca2+ extrusion, thereby limiting Ca2+-induced NAD(P)H production and modulating matrix redox state [LiteratureReference:8951469] Functional reconstitution of the mitochondrial Ca2+/H+ antiporter Letm1 [LiteratureReference:8951454] Genome-wide RNAi screen identifies Letm1 as a mitochondrial Ca2+/H+ antiporter [LiteratureReference:8956346] Electroneutral K+/H+ exchange in mitochondrial membrane vesicles involves Yol027/Letm1 proteins
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	LETM1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)
output	[SimpleEntity:R-ALL-8949232] Ca2+ [mitochondrial intermembrane space] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8949687
summation	[Summation:8951800] LETM1, which is located in the mitochondrial inner membrane ...

Referrals

(precedingEvent)	[Reaction:R-HSA-8949703] SLC8A3 (NCX3) exchanges sodium (cytosol) for calcium (mitochondrial intermembrane space)
(hasEvent)	[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport
(inferredTo)	[Reaction:R-MMU-8951834] Letm1 exchanges protons (mitochondrial intermembrane space) for calcium (mitochondrial matrix)

Cite Us!