Reactome | VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space

Schema > Reaction > Entries

VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space Show undefined attributes

authored	[InstanceEdit:8953749] May, Bruce, 2016-12-27
catalystActivity	[CatalystActivity:8949199] calcium channel activity of VDAC1,2,3 [mitochondrial outer membrane]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	8949145
displayName	VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
edited	[InstanceEdit:8953749] May, Bruce, 2016-12-27
eventOf	[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport - Homo sapiens
followingEvent	[Reaction:R-HSA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Homo sapiens
inferredFrom	[Reaction:R-RNO-8949737] Vdac1 translocates calcium from the cytosol to the mitochondrial intermembrane space - Rattus norvegicus
input	[SimpleEntity:R-ALL-74016] Ca2+ [cytosol]
isChimeric	false
isInDisease	false
isInferred	true
literatureReference	[LiteratureReference:8949760] Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance [LiteratureReference:8949786] Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria [LiteratureReference:8949733] VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria [LiteratureReference:8953522] Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels
maxDepth	1
modified	[InstanceEdit:9830342] Matthews, Lisa, 2023-03-08
name	VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space
output	[SimpleEntity:R-ALL-8949232] Ca2+ [mitochondrial intermembrane space]
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8949145
summation	[Summation:8951802] VDAC1, VDAC2, and VDAC3 are voltage dependent anion channels...

Referrals

(precedingEvent)	[Reaction:R-HSA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
(hasEvent)	[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport
(inferredTo)	[Reaction:R-RNO-8949737] Vdac1 translocates calcium from the cytosol to the mitochondrial intermembrane space

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