Reactome | MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix

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MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix Show undefined attributes

authored	[InstanceEdit:8949206] May, Bruce, 2016-11-21
catalystActivity	[CatalystActivity:8949144] calcium channel activity of MCU complex [mitochondrial inner membrane]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:8949163] May, Bruce, 2016-11-21
crossReference	[DatabaseIdentifier:12667421] RHEA:29671
dbId	8949178
displayName	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
edited	[InstanceEdit:8949206] May, Bruce, 2016-11-21
eventOf	[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport - Homo sapiens
input	[SimpleEntity:R-ALL-8949232] Ca2+ [mitochondrial intermembrane space]
isChimeric	false
isInDisease	false
isInferred	false
literatureReference	[LiteratureReference:8949218] Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter [LiteratureReference:8949222] A forty-kilodalton protein of the inner membrane is the mitochondrial calcium uniporter [LiteratureReference:8949731] Dual functions of a small regulatory subunit in the mitochondrial calcium uniporter complex [LiteratureReference:8949758] Mitochondrial calcium uniporter regulator 1 (MCUR1) regulates the calcium threshold for the mitochondrial permeability transition [LiteratureReference:8949730] Mitochondrial calcium uniporter protein MCU is involved in oxidative stress-induced cell death [LiteratureReference:8949739] Mitochondrial Ca(2+) uniporter (MCU)-dependent and MCU-independent Ca(2+) channels coexist in the inner mitochondrial membrane [LiteratureReference:8949763] MICU1 and MICU2 play nonredundant roles in the regulation of the mitochondrial calcium uniporter [LiteratureReference:8949781] MCU encodes the pore conducting mitochondrial calcium currents [LiteratureReference:8953320] The role of calcium in the regulation of mitochondrial metabolism [LiteratureReference:8953327] MICU1 and MICU2 finely tune the mitochondrial Ca2+ uniporter by exerting opposite effects on MCU activity [LiteratureReference:8949167] MICU2, a paralog of MICU1, resides within the mitochondrial uniporter complex to regulate calcium handling [LiteratureReference:8953330] The mitochondrial calcium uniporter is a multimer that can include a dominant-negative pore-forming subunit [LiteratureReference:8956338] MICU1 encodes a mitochondrial EF hand protein required for Ca(2+) uptake [LiteratureReference:8956341] EMRE is an essential component of the mitochondrial calcium uniporter complex [LiteratureReference:8949723] CCDC90A (MCUR1) is a cytochrome c oxidase assembly factor and not a regulator of the mitochondrial calcium uniporter
maxDepth	1
modified	[InstanceEdit:10996769] Weiser, Joel, 2026-03-16
name	MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
orthologousEvent	[Reaction:R-DDI-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Dictyostelium discoideum [Reaction:R-CEL-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Caenorhabditis elegans [Reaction:R-DME-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Drosophila melanogaster [Reaction:R-GGA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Gallus gallus [Reaction:R-XTR-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Xenopus tropicalis [Reaction:R-DRE-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Danio rerio [Reaction:R-SSC-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Sus scrofa [Reaction:R-BTA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Bos taurus [Reaction:R-CFA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Canis familiaris [Reaction:R-RNO-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Rattus norvegicus [Reaction:R-MMU-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Mus musculus
output	[SimpleEntity:R-ALL-8949220] Ca2+ [mitochondrial matrix]
precedingEvent	[Reaction:R-HSA-8949145] VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space - Homo sapiens [Reaction:R-HSA-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) - Homo sapiens
releaseDate	2017-03-27
reviewStatus	[ReviewStatus:9821382] five stars
reviewed	[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
schemaClass	Reaction
species	[Species:48887] Homo sapiens
stId	R-HSA-8949178
summation	[Summation:8953319] The mitochondrial calcium uniporter (MCU) is a protein compl...

Referrals

(hasEvent)

[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport

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