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Processing of SMDT1
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authored
[InstanceEdit:8949670] May, Bruce, 2016-11-28
created
[InstanceEdit:8949656] May, Bruce, 2016-11-28
dbId
8949664
displayName
Processing of SMDT1
edited
[InstanceEdit:8949670] May, Bruce, 2016-11-28
eventOf
[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport - Homo sapiens
hasDiagram
true
hasEHLD
false
hasEvent
[Reaction:R-HSA-8949661] C2orf47:AFG3L2 binds the transit peptide of SMDT1 - Homo sapiens
[Reaction:R-HSA-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) - Homo sapiens
[Reaction:R-HSA-8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex - Homo sapiens
[BlackBoxEvent:R-HSA-8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU - Homo sapiens
[BlackBoxEvent:R-HSA-8949668] YME1L1 proteolyzes unassembled proSMDT1 - Homo sapiens
isInDisease
false
isInferred
false
literatureReference
[LiteratureReference:8949654] The m-AAA Protease Associated with Neurodegeneration Limits MCU Activity in Mitochondria
maxDepth
2
modified
[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
name
Processing of SMDT1
orthologousEvent
[Pathway:R-CEL-8949664] Processing of SMDT1 - Caenorhabditis elegans
[Pathway:R-DME-8949664] Processing of SMDT1 - Drosophila melanogaster
[Pathway:R-GGA-8949664] Processing of SMDT1 - Gallus gallus
[Pathway:R-DRE-8949664] Processing of SMDT1 - Danio rerio
[Pathway:R-SSC-8949664] Processing of SMDT1 - Sus scrofa
[Pathway:R-BTA-8949664] Processing of SMDT1 - Bos taurus
[Pathway:R-CFA-8949664] Processing of SMDT1 - Canis familiaris
[Pathway:R-RNO-8949664] Processing of SMDT1 - Rattus norvegicus
[Pathway:R-MMU-8949664] Processing of SMDT1 - Mus musculus
releaseDate
2017-03-27
reviewStatus
[ReviewStatus:9821382] five stars
reviewed
[InstanceEdit:8956337] Drago, Ilaria, 2017-01-21
schemaClass
Pathway
species
[Species:48887] Homo sapiens
stId
R-HSA-8949664
summation
[Summation:8953485] Proteolytic processing of proSMDT1 (proEMRE) regulates assem...
Referrals
(hasEvent)
[Pathway:R-HSA-8949215] Mitochondrial calcium ion transport
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