VDAC1,2,3 translocate calcium from the cytosol to the mitochondrial intermembrane space

Stable Identifier
Reaction [transition]
Homo sapiens
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VDAC1, VDAC2, and VDAC3 are voltage dependent anion channels that also preferentially transport divalent calcium ions (Ca2+) in their closed state (Rapizzi et al. 2002, De Stefani et al. 2012, Checchetto et al. 2014, and inferred from rat VDAC1). VDAC1, VDAC2, and VDAC3, located in the mitochondrial outer membrane, transport Ca2+ from the cytosol to the mitochondrial intermembrane space. Transfer of cytosolic calcium to the intermembrane space appears to occur preferentially at sites where the endoplasmic reticulum is in close proximity to the mitochondrial outer membrane. This apposition is due to the physical interaction of VDAC channels on the mitochondrial outer membrane with the ITPR1 (IP3R) channel on the endoplasmic reticulum via the chaperone HSPA9 (GRP75) (Szabadkai et al. 2006).
Literature References
PubMed ID Title Journal Year
21720385 VDAC1 selectively transfers apoptotic Ca2+ signals to mitochondria

Bononi, A, Messina, A, Romagnoli, A, De Stefani, D, Rizzuto, R, Pinton, P, De Pinto, V

Cell Death Differ. 2012
17178908 Chaperone-mediated coupling of endoplasmic reticulum and mitochondrial Ca2+ channels

Balla, T, Wieckowski, MR, Cavagna, D, Nagy, AI, Rizzuto, R, Várnai, P, Bianchi, K, De Stefani, D, Szabadkai, G

J. Cell Biol. 2006
25171321 Recombinant human voltage dependent anion selective channel isoform 3 (hVDAC3) forms pores with a very small conductance

Szabò, I, Reina, S, De Pinto, V, Checchetto, V, Magrì, A

Cell. Physiol. Biochem. 2014
12438411 Recombinant expression of the voltage-dependent anion channel enhances the transfer of Ca2+ microdomains to mitochondria

Baird, G, Tuft, RA, Wieckowski, MR, Pinton, P, Rizzuto, R, Fogarty, KE, Rapizzi, E, Vandecasteele, G, Szabadkai, G

J. Cell Biol. 2002
Catalyst Activity

calcium channel activity of VDAC1,2,3 [mitochondrial outer membrane]

Inferred From
Cross References
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