Reactome | CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]

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CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Homo sapiens
created	[InstanceEdit:8941922] Orlic-Milacic, Marija, 2016-10-07
dbId	8941921
displayName	CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]
hasComponent	[Complex:R-HSA-8941896] CDK4,CDK6:CCND [cytosol] [CandidateSet:R-HSA-8941923] CDKN1A,CDKN1B,(CDKN1C) [cytosol]
inDisease	false
inferredTo	[Complex:R-MMU-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Mus musculus [Complex:R-RNO-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Rattus norvegicus [Complex:R-CFA-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Canis familiaris [Complex:R-BTA-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Bos taurus [Complex:R-SSC-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Sus scrofa [Complex:R-DRE-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Danio rerio [Complex:R-XTR-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Xenopus tropicalis [Complex:R-GGA-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Gallus gallus [Complex:R-DME-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Drosophila melanogaster [Complex:R-CEL-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol] - Caenorhabditis elegans
isChimeric	false
literatureReference	[LiteratureReference:77490] New functional activities for the p21 family of CDK inhibitors. [LiteratureReference:8941906] P27Kip1 and p21Cip1 are not required for the formation of active D cyclin-cdk4 complexes [LiteratureReference:8941907] Genetic characterization of the role of the Cip/Kip family of proteins as cyclin-dependent kinase inhibitors and assembly factors
maxDepth	4
memberOf	[CandidateSet:R-HSA-8949872] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol] - Homo sapiens
modified	[InstanceEdit:8948134] Orlic-Milacic, Marija, 2016-11-10
name	CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) CDK4/6:CCND:CDKN1A/B/C
producedByEvent	[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Homo sapiens
schemaClass	Complex
species	[Species:48887] Homo sapiens
stId	R-HSA-8941921

Referrals

(input)	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
(output)	[Reaction:R-HSA-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes
(hasMember)	[CandidateSet:R-HSA-8949872] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C); CDK4,CDK6:CCND; (CDK4,CDK6:CCND:p-Y88-CDKN1B) [cytosol]

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