Reactome | Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes

Schema > Reaction > Entries

Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes Show undefined attributes

catalystActivity	[CatalystActivity:10204833] protein tyrosine kinase activity of (p-Y342-PTK6,p-Y397-LYN,p-Y226,Y393-ABL1,p-Y419-SRC,p-5Y-JAK2) [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10102717] Weiser, Joel, 2026-03-16
dbId	10204835
displayName	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
eventOf	[Pathway:R-RNO-69231] Cyclin D associated events in G1 - Rattus norvegicus
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-RNO-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus - Rattus norvegicus
inferredFrom	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-RNO-8941921] CDK4,CDK6:CCND:CDKN1A,CDKN1B,(CDKN1C) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-RNO-8942622] CDK4/6:CCND:p-Y77-CDKN1A,p-Y88-CDKN1B,(p-Y91-CDKN1C) [cytosol]
precedingEvent	[Reaction:R-RNO-8941915] Cip/Kip CDK inhibitors bind CDK4/6:CCND complexes - Rattus norvegicus
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:48895] Rattus norvegicus
stId	R-RNO-8942607
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-RNO-69231] Cyclin D associated events in G1
(precedingEvent)	[BlackBoxEvent:R-RNO-8942803] Translocation of CDK4/6:CCND complexes from the cytoplasm to the nucleus
(inferredTo)	[Reaction:R-HSA-8942607] Tyrosine kinases phosphorylate Cip/Kip inhibitors bound to CDK4/6:CCND complexes

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